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"Combination therapy in recurrence of enuresis"

Recurrence of primary enuresis after treatment with desmopressin compare with combination therapy desmopressin and tolterodine in children aged 5-16 years

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20210714051893N1
Enrollment
124
Registered
2021-08-22
Start date
2021-09-23
Completion date
Unknown
Last updated
2021-08-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Primary monocympetic nocturnal enuresis. Nacturnal enuresis

Interventions

Intervention 1: Control group: Patients will be randomly divided into two groups: (CCTT) by random allocation with variable blocks that create six different states. CTCT. CTTC. TTCC TCTC. (TCCT) and t

Sponsors

Qazvin University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
5 Years to 16 Years

Inclusion criteria

Inclusion criteria: Patients have monosymptomatic primary enuresis. Patients without any anatomical disorder of kidney in sonography Patients aged 5 -16 years Knowledgeably compliance for entry or exit from research

Exclusion criteria

Exclusion criteria: Patients with enuresis with symptoms of daily urinary disorders, such as urgent urinary incontinence, frequent urination, or reduced urination frequency per day, urinary retention maneuvers during the day. Patients with urinary tract infection (positive urine culture), fasting blood sugar, renal dysfunction (high creatinine), Anatomical abnormalities of the kidney on ultrasound, patients previously treated for enuresis patients with incomplete information, and no referrals if the child does not have enuresis (has gained control of urination) and later has enuresis secondary enuresis

Design outcomes

Primary

MeasureTime frame
Nocturnal enuresis. Timepoint: After starting treatment, patients will be visited monthly. If there is a partial or no response up to two weeks after treatment, possible factors of resistance to treatment such as constipation, bladder disorders or not taking the drug properly will be investigated. Failure to respond to treatment refers to one or more night wetting in two consecutive weeks during treatment and response to treatment is defined as dryness in two consecutive weeks.After three months of treatment, the drugs are discontinued overnight for one month. Re-visits are performed two weeks after treatment and recurrence of nocturnal enuresis (more than three nights wetting per week) will be checked. Method of measurement: Response to treatment questionnaire.

Secondary

MeasureTime frame
Early enuresis recurrence. Timepoint: En After starting treatment, patients will be visited monthly. If there is a partial or no response up to two weeks after treatment, possible factors of resistance to treatment such as constipation, bladder disorders or not taking the drug properly will be investigated. Failure to respond to treatment refers to one or more night wetting in two consecutive weeks during treatment and response to treatment is defined as dryness in two consecutive weeks.After three months of treatment, the drugs are discontinued overnight for one month. Re-visits are performed two weeks after treatment and recurrence of nocturnal enuresis (more than three nights wetting per week) will be checked. Method of measurement: En Response to treatment questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFereshteh Sobhani

Qazvin University of Medical Sciences

fereshteh.sobhani23@gmail.com+98 28 3333 4807

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026