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The effect of vitamin C in the treatment of patients with COVID-19

Evaluation of the effect of high-dose vitamin C in the treatment of patients with COVID-19 admitted to the critical care ward

Status
Recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20210714051891N1
Enrollment
200
Registered
2021-09-29
Start date
2021-10-07
Completion date
Unknown
Last updated
2021-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19 patients. COVID-19, virus identified

Interventions

Intervention 1: Intervention group: Vitamin C is made by Osweh Pharmaceutical Company, will be administered 4 grams by injection every 12 hours for 10 days. Intervention 2: Control group: They will no

Sponsors

Tabriz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Respiratory failure index (RIF) Treated in the ICU

Exclusion criteria

Exclusion criteria: Patients with a history of vitamin C allergy. Patients with asthma due to cardiopulmonary edema Pregnant or lactating women Patients with a survival time of less than 24 hours Patients with a history of end-stage lung disease, end-stage malignant tumor, G-6-PD deficiency, diabetic ketoacidosis, active kidney stone disease, and severe kidney disease Patients who have already enrolled in another clinical trial Patients with a known history of kidney disease, chronic renal failure, or acute renal failure during hospitalization

Design outcomes

Primary

MeasureTime frame
The amount of lung involvement in a CT scan. Timepoint: Every 12 hours, Up to 10 days. Method of measurement: According to the radiologist, the appearance of lung involvement and the percentage of lung involvement are measured.

Secondary

MeasureTime frame
Oxygen saturation. Timepoint: Every 12 hours, Up to 10 days. Method of measurement: Observations and clinical examinations.;Respiratory rate. Timepoint: Every 12 hours, Up to 10 days. Method of measurement: Observations and clinical examinations.;Duration of hospitalization. Timepoint: Daily since hospitalization time. Method of measurement: Based on patient records.;Mortality rate. Timepoint: Daily. Method of measurement: Census.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMoloud Balafar

Tabriz University of Medical Sciences

m.balafar@yahoo.com+98 41 3335 2078

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026