The effect of plasma therapy in the treatment of patients with COVID-19

The effect of plasma therapy in the treatment of patients with COVID-19 infection. Randomized, open-label

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210714051887N1

Enrollment

Registered

2022-05-18

Start date

2020-09-21

Completion date

Unknown

Last updated

2022-05-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19 infection. Pneumonia due to SARS-associated coronavirus

Interventions

Intervention 1: Intervention group: Intervention group: In the intervention group, patients receive 200 ml of convalescent plasma for one turn Improved plasma for one turn in addition to the standard

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Willingness to participate in the studyPeople over the age of 18People with severe form of COVID-19 disease (shortness of breath, respiratory frequency = 30 / min,, blood oxygen saturation = 93%,, partial pressure of arterial oxygen to fraction of inspired oxygen ratio <300,, percentage of pulmonary involvement more than 50 in 24-48 hours,)

Exclusion criteria

Exclusion criteria: -

Design outcomes

Primary

Measure	Time frame
Body temperature. Timepoint: On days two, three and 7 after hospitalization and receiving plasma. Method of measurement: Thermometer device.;Blood Saturated Oxygen Levels. Timepoint: On days two, three and 7 after hospitalization and receiving plasma. Method of measurement: Pulse oximeter.;C-reactive protein (CRP) Factor. Timepoint: On days two, three and 7 after hospitalization and receiving plasma. Method of measurement: Blood Test.	—

Measure

Time frame

Body temperature. Timepoint: On days two, three and 7 after hospitalization and receiving plasma. Method of measurement: Thermometer device.;Blood Saturated Oxygen Levels. Timepoint: On days two, three and 7 after hospitalization and receiving plasma. Method of measurement: Pulse oximeter.;C-reactive protein (CRP) Factor. Timepoint: On days two, three and 7 after hospitalization and receiving plasma. Method of measurement: Blood Test.

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Secondary

Measure	Time frame
Duration of hospitalization of the patient. Timepoint: End of hospitalization or death of the patient. Method of measurement: By day.;Heart rate. Timepoint: On days two, three and 7 after hospitalization and receiving plasma (patient receives plasma treatment on the second day of hospitalization. Method of measurement: Monitoring device.;Lung lesions on CT scan. Timepoint: On days two, three and 7 after hospitalization and receiving plasma (patient receives plasma treatment on the second day of hospitalization). Method of measurement: Lung lesions with lung CT scan.;D-dimer Factor. Timepoint: On days two, three and 7 after hospitalization and receiving plasma (patient receives plasma treatment on the second day of hospitalization. Method of measurement: blood test.	—

Measure

Time frame

Duration of hospitalization of the patient. Timepoint: End of hospitalization or death of the patient. Method of measurement: By day.;Heart rate. Timepoint: On days two, three and 7 after hospitalization and receiving plasma (patient receives plasma treatment on the second day of hospitalization. Method of measurement: Monitoring device.;Lung lesions on CT scan. Timepoint: On days two, three and 7 after hospitalization and receiving plasma (patient receives plasma treatment on the second day of hospitalization). Method of measurement: Lung lesions with lung CT scan.;D-dimer Factor. Timepoint: On days two, three and 7 after hospitalization and receiving plasma (patient receives plasma treatment on the second day of hospitalization. Method of measurement: blood test.

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Countries

Iran (Islamic Republic of)

Contacts

Public Contactmasood ziaee

Birjand University of Medical Sciences

dr.ziaee@gmail.com+98 56 3162 2430

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026