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Comparison of the effectiveness of ketamine and ketorolac to control pain in patients with at least two rib fractures and patients in need of chest tube insertion

Comparison of the effectiveness of ketamine and ketorolac infusion to control pain in adult patients

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20210711051840N1
Enrollment
90
Registered
2023-04-29
Start date
2023-04-30
Completion date
Unknown
Last updated
2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pain management. Pleurodynia

Interventions

Intervention 1: We inject 0.25 mg/kg of ketamine and prepare a 5 cc syringe in 5 minutes infusion for the study patients. Intervention 2: We inject the dose of 30 mg of ketorolac and prepare a 5 cc sy

Sponsors

Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Age over 18 years 2. Patients with blunt and penetrating trauma, with a fracture of two ribs or more, or patients who need a chest tube insertion.

Exclusion criteria

Exclusion criteria: 1. People who have a history of allergies and drug reactions, especially to ketamine. 2. People with <= 13 GCS 3. People with acute coronary syndrome 4. Increase ICP 5. Severe hypertension (systolic pressure = and <from 180 mm Hg or diastolic = and <from 100 mm Hg) 6. People who are currently taking MAO inhibitors. 7. People with a history of psychosis 8. Consumers of psychiatric drugs (Pschycotropic) 9. Active dementia or delirium 10. Glaucoma 11. Pregnancy 12. Inability to express pain or communicate with people 13. Liver failure 14. Patients with active bleeding 15. Patients with gastric ulcer 16. Thrombocytopenia

Design outcomes

Primary

MeasureTime frame
Percentage of pain relief in response to ketamine. Timepoint: The basis of the amount of pain reported by the patient is measured at time zero (before drug injection), 5, 30 and then every 30 minutes to two hours. Method of measurement: Numerical Rating Scale(NRS).

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHosein Zabihi

Tehran University of Medical Sciences

zeynabsdjvdn@gmail.com00982163120

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026