Weight gain side effect in patients with schizophrenia receiving atypical antipsychotics. Schizophrenia
Conditions
Interventions
Intervention 1: Simultaneously with the continuous use of antipsychotic drugs, in the intervention group, Schizoherb capsules (including three herbs green tea, Persian borage and portulaca oleracea, f
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Age range 18 to 65 years No serious systemic disease (including liver or kidney failure, known heart disease, hypothyroidism, hypertension) based on history and physical examination and lab tests and approved by a psychiatrist No changes in the type and dose of antipsychotic drug in at least the last 3 months
Exclusion criteria
Exclusion criteria: Dependence on substances (except cigarettes) Women during pregnancy or lactation Liver functional tests more than twice normal History of allergies to any of the plants in the design Consumers of aripiprazole
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Weight. Timepoint: Before the beginning of study (week zero) and the end of study (week eight). Method of measurement: Measuring body weight (in kilograms) and height (in meters) and calculating body mass index or BMI (in kg / m2), measuring waist circumference with a tape measure (in centimeters) and calculating WHR (waist- hip circumference ratio). | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluation of the severity of positive and negative symptoms of schizophrenia. (According to the available articles, the herbs used in the design are expected to be effective in reducing negative symptoms. In most interventional studies in schizophrenic patients, the severity of symptoms is assessed during the study.). Timepoint: weeks 0, 4 , 8. Method of measurement: PANSS questionnaire.;Fasting blood suger. Timepoint: beginning and end of the study. Method of measurement: by blood sample (in mg/dl).;Lipid profile. Timepoint: beginning and end of the study. Method of measurement: by blood sample (in mg/dl).;Measuring blood pressure. Timepoint: beginning and end of the study. Method of measurement: Using a mercury barometer (in mmhg).;Check the quality of life. Timepoint: beginning and end of the study. Method of measurement: Using the World Health Organization quality of life questionnaire (WHOQol - Bref). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHamideh Naghibi
Mashhad University of Medical Sciences
Outcome results
None listed