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Neoadjuvant chemotherapy in advanced gastric cancer

Neoadjuvant chemotherapy in advanced gastric cancer: a comparative pilot study on treatment response and side effects

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20210703051769N2
Enrollment
40
Registered
2024-11-05
Start date
2024-11-02
Completion date
Unknown
Last updated
2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastric cancer. Malignant neoplasm of stomach

Interventions

Intervention 1: The first group received an EOX treatment regimen (Epirubicin 50 mg/m2 day 1, Oxaliplatin 130 mg/m2 day 1, and Capecitabine 625 mg/m2, BD, day 1 through 21) for three weeks. Interventi

Sponsors

Qazvin University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Age above 18 years normal bone marrow function (hemoglobin >10 g/dL, absolute neutrophil count >3000/µL, platelet count >100,000/µL) Kidney dysfunction (GFR >45 mL/min/1.73 m²) Liver dysfunction (serum bilirubin 55%

Exclusion criteria

Exclusion criteria: Presence of any active or acute infection requiring systemic antibiotics History of any active autoimmune disease or immunodeficiency-related condition. History of significant heart disease, such as uncontrolled heart failure or coronary artery disease. Presence of any other active malignancy (except those that are treated and controlled). Use of medications that may interfere with the study interventions, with inability to discontinue them. History of severe allergy or hypersensitivity reactions to drugs or materials used in the study. Presence of psychiatric conditions that may affect informed consent or effective participation in the study.

Design outcomes

Primary

MeasureTime frame
Response rate to treatment. Timepoint: 21 days after the start of treatment. Method of measurement: Sonography.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactEnsiyeh Bahadoran

Qazvin University of Medical Sciences

bahadoran.ensiyeh@gmail.com+98 912 768 9597

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026