Condition 1: Hypothyroidism. Condition 2: Impaired glucose tolerance. Condition 3: Overweight and obesity. Other hypothyroidism Impaired glucose tolerance (oral) Overweight and obesity
Conditions
Interventions
Intervention 1: Intervention group: For 12 weeks, receive vitamin D3 supplement daily (containing 4000 IU of vitamin D3, produced by Zahravi Pharmaceutical Company). Intervention 2: For 12 weeks, they
Sponsors
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 75 Years
Inclusion criteria
Inclusion criteria: Individuals between 20 and 75 years old. Overweight or obese individuals with a body mass index above 25. Individuals Suffering from hypothyroidism with TSH levels higher than 7 microIU/ml. Individuals with impaired glucose tolerance with fasting plasma glucose levels above 100 mg/dL or 2-hour plasma glucose above 140 mg / dL. Individuals with serum 25-hydroxyvitamin D3 concentration is less than 30 ng/ml.
Exclusion criteria
Exclusion criteria: Individuals with cancer, kidney, liver, cardiovascular, bone, and endocrine diseases other than hypothyroidism and glucose intolerance disorders. Individuals taking drugs related to diseases such as cancer, kidney, liver, heart, and drugs that affect bone metabolism (estrogen, selective estrogen receptor modulator, bisphosphonate, vitamin D, or calcium). Individuals consuming multivitamins-minerals. Pregnant and lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Insulin resistance: A disorder of glucose homeostasis that is defined as a decrease in the sensitivity of adipose tissue, liver, liver, and other body tissues to insulin, despite normal or elevated levels of insulin in the blood. Timepoint: At the beginning of the study (before the intervention) and 12 weeks later at the end of the intervention. Method of measurement: Using the formula HOMA-IR: [Fasting insulin(mIU/L) × fasting glucose(mg/dL)]/405. | — |
Secondary
| Measure | Time frame |
|---|---|
| Weight: Weight of a person with light minimum possible clothes and without shoes with an accuracy of 100 grams. Timepoint: At the beginning of the study (before the intervention) and 12 weeks later at the end of the intervention. Method of measurement: Scales.;BMI: [Weight(kg)]/[height (cm) * height (cm)]. Timepoint: At the beginning of the study (before the intervention) and 12 weeks later at the end of the intervention. Method of measurement: Formula.;Waist Circumference: the smallest circumference of waist in centimeters. Timepoint: At the beginning of the study (before the intervention) and 12 weeks later at the end of the intervention. Method of measurement: Tape measure.;Serum TSH. Timepoint: At the beginning of the study (before the intervention) and 12 weeks later at the end of the intervention. Method of measurement: ELISA.;Serum T3. Timepoint: At the beginning of the study (before the intervention) and 12 weeks later at the end of the intervention. Method of measurement: ELISA.;Serum T4. Timepoint: At the beginning of the study (before the intervention) and 12 weeks later at the end of the intervention. Method of measurement: Eliza.;Fasting serum insulin. Timepoint: At the beginning of the study (before the intervention) and 12 weeks later at the end of the intervention. Method of measurement: Spectrophotometer.;Fasting serum glucose. Timepoint: At the beginning of the study (before the intervention) and 12 weeks later at the end of the intervention. Method of measurement: Spectrophotometer.;HbA1c. Timepoint: At the beginning of the study (before the intervention) and 12 weeks later at the end of the intervention. Method of measurement: Spectrophotometer.;Serum LDL-c. Timepoint: At the beginning of the study (before the intervention) and 12 weeks later at the end of the intervention. Method of measurement: Spectrophotometer.;Serum HDL-c. Timepoint: At the beginning of the study (before the intervention) and 12 weeks later at the end of the intervention. M | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Mohammad Hassan Eftekhari
Shiraz University of Medical Sciences
Outcome results
None listed