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Comparison the Effect of Remifentanil-Thiopental and Ketofol in major depression

Comparison the Effect of Remifentanil-Thiopental and Ketofol on Homodynamic Responses in Patients with Major depressive disorder candidates for Electro Convulsive Therapy

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20210622051672N1
Enrollment
80
Registered
2021-07-22
Start date
2021-09-23
Completion date
Unknown
Last updated
2021-08-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Major depressive disorder. Major depressive disorder, single episode, unspecified

Interventions

Intervention 1: Intervention group: In group B, the anesthesia process is induced by intravenous injection of 0.5 mg / kg Ketamine with 0.5 mg / kg Propofol (Ketofol) and injection of 0.5 mg / kg Succ

Sponsors

Arak University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: All patients with major depressive disorder candidates for Electro Convulsive Therapy referred to Arak Amirkabir Hospital All patients candidates for Electro-Convulsive Therapy who have signed an informed consent form to enter the study Patients in the age range of 18 to 60 years Patients with a BMI in the range of 20 to 30 Patients with major depressive disorder who do not have another psychiatric illness at the same time

Exclusion criteria

Exclusion criteria: Pregnancy Breastfeeding sensitivity to Remifentanil or Thiopental or Propofol taking anticonvulsant drugs recent CVA or MI history history of underlying diseases of the heart, lungs, kidneys and liver

Design outcomes

Primary

MeasureTime frame
Mean Arterial Pressure. Timepoint: Beginning and the end of recovery. Method of measurement: Monitor.;Pulse Rate. Timepoint: Beginning and the end of recovery. Method of measurement: Monitor.;Pulse oximetry (SpO2). Timepoint: Beginning and the end of recovery. Method of measurement: Monitor.;Satisfaction score. Timepoint: After recovery. Method of measurement: questionnaire.;Agitation Score. Timepoint: After recovery. Method of measurement: questionnaire.;Duration of seizures. Timepoint: beginning and the end of seizures. Method of measurement: Minutes with chronometer.;Duration of recovery. Timepoint: Beginning and the end of recovery. Method of measurement: Chronometer.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Alireza Kamali

Arak University of Medical Sciences

alikamaliir@yahoo.com+98 86 3222 2003

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026