CHEMOTHERAPY,MUCOSITIS,RADIATION THERAPY,CANCER. Oral mucositis (ulcerative) due to antineoplastic therapy
Conditions
Interventions
Intervention 1: Intervention group: Patients treated with N-acetylcysteine tablets (200 mg) produced by a pharmaceutical company. The intervention group started the treatment on the first day with a d
Sponsors
Ahvaz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
2 Years to 18 Years
Inclusion criteria
Inclusion criteria: Patients who are 2-18 years old Recipients of radiotherapy and anti-metabolite chemotherapy drugs with a high risk of developing oral mucositis (including Doxorubicin, Methotrexate, FU Etoposide, Cytarabine and Melphalan) and other drugs listed below. Patients with lansky performance scale index above 70% No Cardiovascular disease
Exclusion criteria
Exclusion criteria: Causes any severe allergic reactions to the drug (such as skin complications, bronchospasm, bronchitis, etc.) Any active gastrointestinal disease Cardiovascular disease
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| The level of the oxidative stress factor Malondialdehyde in the blood. Timepoint: Measurement of the oxidative stress factor Malondialdehyde at the beginning of the study (before the start of the intervention) and 7, 15 days after the start of taking N-acetylcysteine. Method of measurement: Measurement of Malondialdehyde oxidative stress factor in patient's blood by UV spectrophotometry. | — |
Primary
| Measure | Time frame |
|---|---|
| The score of positive and negative symptoms in the PANSS questionnaire. Timepoint: Prevention of mucositis caused by radiotherapy at the beginning of the study (before the start of the intervention) and 7, 15 days after the start of taking N-acetylcysteine. Method of measurement: Questionnaire of positive and negative symptoms of oral mucositis. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSepideh Dadfar
Ahvaz University of Medical Sciences
Outcome results
None listed