Endometrioma. Endometriosis of ovary
Conditions
Interventions
Intervention 1: Intervention group: Participants who randomly assigned in the intervention group, during 6 weeks simultaneous to start standard long agonist protocol or antagonist induction, will be
Sponsors
Royan Institute
Eligibility
Sex/Gender
Female
Age
20 Years to 42 Years
Inclusion criteria
Inclusion criteria: Age between 20 and 42 years old Ultrasound or laparoscopic diagnosis of moderate to sever endometrioma (endometriosis stage III and IV) Serum AMH levels between 0.7 and 4.5 ng/ml Standard long GnRH and antagonist ovulation stimulation cycle Body mass index (BMI) <30 kg/m2
Exclusion criteria
Exclusion criteria: Non-inclusion criteria: Congenital uterine malformations Severe male infertility (TESE, PESA) Past medical history of asthma
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MII oocyte number and quality. Timepoint: Immediately after oocyte puncture. Method of measurement: Observation of oocytes that were mature at the time of oocyte collection. | — |
Secondary
| Measure | Time frame |
|---|---|
| Measurement of TAC oxidative stress marker in blood plasma. Timepoint: Before intervention and 6 weeks after intervention. Method of measurement: ELISA.;Measurement of SOD oxidative stress marker in blood plasma. Timepoint: Before intervention and 6 weeks after intervention. Method of measurement: ELISA.;Measurement of TAC oxidative stress marker in folicular fluid. Timepoint: After oocyte puncture. Method of measurement: ELISA.;Measurement of SOD oxidative stress marker in folicular fluid. Timepoint: After oocyte puncture. Method of measurement: ELISA.;Cleaved embryo numbers. Timepoint: 2-3 days after oocyte puncture. Method of measurement: 2-3 days embryo from fertilization.;Blastocyst numbers. Timepoint: 5 days after oocyte puncture and sperm insemination. Method of measurement: The stage the embryo reaches after 5 days in culture from the egg retrieval.;Clinical pregnancy rate. Timepoint: 4-6 weeks after embryo transfer. Method of measurement: The observation of gestational sac on ultrasound examination two-three weeks after positive serum ßhCG.;Fertilization rate. Timepoint: 2-5 days after sperm insemination. Method of measurement: Percentage of transformation of micro injected oocytes into two pronuclei embryo. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactParvaneh Afsharin
Royan Institute
Outcome results
None listed