Effects of exercise training and vitamin D supplementation on Migraine

Effects of 8 weeks of aerobic exercise and vitamin D supplementation on serum levels of brain-derived neurotrophic factor, quality of life, and some cognitive and psychological indices in Migraine patients

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210617051606N3

Enrollment

Registered

2021-10-27

Start date

2021-10-07

Completion date

Unknown

Last updated

2021-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Migraine without aura. Migraine without aura

Interventions

Intervention 1: Intervention group: continuous aerobic exercise for 8 weeks and 3 sessions per week. In the first week, the duration of training will be 20 minutes and the intensity will be 50% of hea

Eligibility

Sex/Gender

Male

Age

20 Years to 50 Years

Inclusion criteria

Inclusion criteria: Not participation in regular exercise over the last 6 months Having Migraine without aura confirmed by a specialist Getting the certification of no prohibition of participating in the exercise training program from a specialist Insufficient values of Vitamin D (20-29 nanograms/milliliter) Aged between 20 to 50 years

Exclusion criteria

Exclusion criteria: Any psychiatric disorders other than Migraine without aura Alcohol and other kinds of drug addiction Musculoskeletal disorder Cardiovascular and pulmonary diseases Refusal to give informed consent

Design outcomes

Secondary

Measure	Time frame
Changes in depression severity. Timepoint: Before starting the intervention, and 8 weeks after starting the intervention. Method of measurement: By the use of Beck’s Depression Inventory.;Change in the quality of sleep. Timepoint: Before intervention and after 8 weeks of intervention. Method of measurement: Pittsburgh Sleep Quality Index.;Change in physical self-concept. Timepoint: Before intervention and after 8 weeks of intervention. Method of measurement: Physical self-concept questionnaire.	—

Measure

Time frame

Changes in depression severity. Timepoint: Before starting the intervention, and 8 weeks after starting the intervention. Method of measurement: By the use of Beck’s Depression Inventory.;Change in the quality of sleep. Timepoint: Before intervention and after 8 weeks of intervention. Method of measurement: Pittsburgh Sleep Quality Index.;Change in physical self-concept. Timepoint: Before intervention and after 8 weeks of intervention. Method of measurement: Physical self-concept questionnaire.

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Primary

Measure	Time frame
Change in serum levels of brain-derived neurotrophic factor. Timepoint: Before starting the intervention, and 8 weeks after starting the intervention. Method of measurement: By the use of blood sample and ELISA method.;Change in quality of life. Timepoint: Before starting the intervention, and 8 weeks after starting the intervention. Method of measurement: World health organization standard quality of life questionnaire (short version).;Changes in severity, duration, and frequency of Migraine attacks. Timepoint: Before starting the intervention, and 8 weeks after starting the intervention. Method of measurement: By the use of researcher-made questionnaire to record the pertinent variables of Migraine attacks.;Changes in memory performance. Timepoint: Before starting the intervention, and 8 weeks after starting the intervention. Method of measurement: By the use of Subjective Memory Complaints Scale.;Changes in cognitive performance. Timepoint: Before starting the intervention, and 8 weeks after starting the intervention. Method of measurement: By the use of Ascertain Dementia 8 (AD8) questionnaire.	—

Measure

Time frame

Change in serum levels of brain-derived neurotrophic factor. Timepoint: Before starting the intervention, and 8 weeks after starting the intervention. Method of measurement: By the use of blood sample and ELISA method.;Change in quality of life. Timepoint: Before starting the intervention, and 8 weeks after starting the intervention. Method of measurement: World health organization standard quality of life questionnaire (short version).;Changes in severity, duration, and frequency of Migraine attacks. Timepoint: Before starting the intervention, and 8 weeks after starting the intervention. Method of measurement: By the use of researcher-made questionnaire to record the pertinent variables of Migraine attacks.;Changes in memory performance. Timepoint: Before starting the intervention, and 8 weeks after starting the intervention. Method of measurement: By the use of Subjective Memory Complaints Scale.;Changes in cognitive performance. Timepoint: Before starting the intervention, and 8 weeks after starting the intervention. Method of measurement: By the use of Ascertain Dementia 8 (AD8) questionnaire.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactEhsan Amiri

Razi University

e.amiri@razi.ac.ir+98 83 3845 8428

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026