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"Effect of Mirtazapine on aggression in patients with Alzheimer"

The effect of adding Mirtazapine to quetiapine on reducing aggression in patients with Alzheimer's dementia

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20210613051565N1
Enrollment
52
Registered
2021-07-19
Start date
2021-07-23
Completion date
Unknown
Last updated
2021-08-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alzheimer's dementia. Alzheimer's disease

Interventions

Intervention 1: Intervention group: Patients with entry criteria who have symptoms of agitation or aggression. These patients are treated with Quetiapine(Abidi company) and during 2-4 weeks, the dose

Sponsors

University of social welfare and rehabilitation sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Adult patients (over the age of 18) With Alzheimer's dementia At least two years have passed since the onset of the disease Confirm by a neurologist or psychiatrist with the NIA-AA (2011 National Institute on Aging and Alzheimer's Association) diagnostic criteria assistant. Participant's consent Cohen-Mansfield Agitation Inventory (CMAI) test score more than 45

Exclusion criteria

Exclusion criteria: No psychiatric disability No physical disability No neurological disability Any disease with significant cognitive Impairment, (mental retardation) No substance abuse in the previous six months No extra psychiatric medication

Design outcomes

Primary

MeasureTime frame
-Cognitive changes by the MMSE - symptoms of agitation and aggression by the CMAI. Timepoint: In 0,4,6 weeks. Method of measurement: Questionnaire Mini–mental state examination(MMSE) ,Questionnaire Cohen Mansfield Agitation Inventory(CMAI).

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSahar Darvishskandari

University of social welfare and rehabilitation sciences

saharskandari1975@gmail.com+98 21 2200 7927

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026