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Comparison of the effect of intraarticular and periarticular injection of cocktail of morphin epinephrin ropivacain ketorolac on eliminating the postoperative pain after total knee arthroplasty in patients with knee degenerative joint disease

Comparison of the effect of intraarticular and periarticular injection of cocktail of morphin epinephrin ropivacain ketorolac on eliminating the postoperative pain after total knee arthroplasty in patients with knee degenerative joint disease

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20210613051559N1
Enrollment
96
Registered
2021-06-19
Start date
2021-06-15
Completion date
Unknown
Last updated
2021-06-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

knee degenerative joint disease.

Interventions

Intervention 1: Intervention group: intrarticular analgesic cocktail (MS, ropivacain, ketorolac, epinephrin) injection 100 cc. Intervention 2: Intervention group: periarticular injection of analgesic

Sponsors

Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: those aged 18-80 weight between 50-120 kg ability to read, write and complete informed consent

Exclusion criteria

Exclusion criteria: drug sensitivity drug dependence neurologic disease psychiatric illness cardiac disease liver disease cardiac arrythmia Diabetes neuromuscular problem inflammatory arthritis e.g. RA renal disease

Design outcomes

Primary

MeasureTime frame
Amount of post operative morphin sulfate injection after the total knee arthroplasty. Timepoint: during 72 hr after the total knee arthroplasty. Method of measurement: mg morphin injected by the nursery and documented in the patien's documents.

Secondary

MeasureTime frame
Visual analogue scale. Timepoint: during 72 h postoperatively 1 week and 1 months after surgery. Method of measurement: 1 to 10 based on the VAS scale.;WOMAC. Timepoint: 1 DAY before OR, 1 week and 1 month after OR. Method of measurement: womac scale.;KSS. Timepoint: 1 DAY before OR, 1 week and 1 month after OR. Method of measurement: KSS scale.

Countries

Iran (Islamic Republic of)

Contacts

Public Contactseyed mohammad javad mortazavi

Tehran University of Medical Sciences

smjmort@yahoo.com+98 21 8827 0873

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026