Skin wrinkles. Other specified disorders of the skin and subcutaneous tissue
Conditions
Interventions
Intervention 1: Intervention group: local transplantation of growth factors derived from umbilical cord was designed in 10 candidates with wrinkles. 3 times of growth factors derived from umbilical co
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
35 Years to 65 Years
Inclusion criteria
Inclusion criteria: Wrinkle lines on the face should be in the range of 3-5 based on Wrinkle Severity Rating Scale
Exclusion criteria
Exclusion criteria: Suffering from uncontrolled chronic diseases including diabetes mellitus, underlying chronic liver, kidney and heart disease, chronic malnutrition malignancy coagulopathy or the use of anticoagulants a history of autoimmune diseases suffering from HBV, HIV, HCV viral infections Any cosmetic procedure such as fat injection within a year and permanent filler, microneedling, Radiofrequency, laser and other cases within the last 6 months, except for using cream. Infection and any malignancy at the transplant recipient site Moderate to severe chronic skin diseases such as eczema and psoriasisactive acne People who have had systemic retinoid treatment (within the last 6 months) or topical retinoid treatment (within the last 2 weeks) Women during pregnancy and breastfeeding Patients undergoing radiotherapy and chemotherapy active acne
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Side effects, including short-term and long-term, systemic or local side effects, and severe or mild side effects in the treatment with growth factors derived from umbilical cord. Timepoint: Zero and 2 weeks, 1, 2, 4 and 6 months after first injection. Method of measurement: Clinical examination and CTCAE v5 review. | — |
Secondary
| Measure | Time frame |
|---|---|
| Wrinkle severity. Timepoint: 2 weeks, 1, 2, 4 and 6 months after first injection. Method of measurement: Wrinkle reduction based on WSRS score reduction six months after injection. Reduction of wrinkles based on the increase in GAIS score two weeks, 1, 4, and 6 months after the first injection. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAmir Bajouri
Tehran University of Medical Sciences
Outcome results
None listed