skin wrinkles. Other specified disorders of the skin and subcutaneous tissue
Conditions
Interventions
Intervention 1: Intervention group: local transplantation of hydrogel derived from decellularized extracellular matrix (ECM) of the umbilical cord was designed in 10 candidates with wrinkles. 3 times
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
35 Years to 65 Years
Inclusion criteria
Inclusion criteria: Wrinkle lines on the face should be in the range of 3-5 based on Wrinkle Severity Rating Scale
Exclusion criteria
Exclusion criteria: Suffering from uncontrolled chronic diseases including diabetes mellitus, underlying chronic liver, kidney and heart disease, chronic malnutrition, malignancy, coagulopathy or the use of anticoagulants, a history of autoimmune diseases and suffering from HBV, HIV, HCV viral infections Any cosmetic procedure such as fat injection within a year and permanent filler, microneedling, RF, laser and other cases within the last 6 months, except for using cream. Infection and any malignancy at the transplant recipient site Failure to receive cells in the treatment area during the past year Patients with vitiligo Moderate to severe chronic skin diseases such as eczema and psoriasis active acne People who have had systemic retinoid treatment (within the last 6 months) or topical retinoid treatment (within the last 2 weeks) History of keloid Women during pregnancy and breastfeeding Patients undergoing radiotherapy and chemotherapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Absence of side effects, including short-term and long-term, systemic or local side effects, and severe or mild side effects in the treatment with hydrogel derived from decellularized umbilical cord ECM (zero and 2 weeks, 1, 2, 4 and 6 months after first injection) through clinical examination and CTCAE v5 review. Timepoint: (zero and 2 weeks, 1, 2, 4 and 6 months after first injection. Method of measurement: Wrinkle reduction based on WSRS score reduction six months after injection. Reduction of wrinkles based on the increase in GAIS score two weeks, 1, 4, and 6 months after the first injection). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAmir Bajouri
Tehran University of Medical Sciences
Outcome results
None listed