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The synergistic effect of repeated transcranial magnetic stimulation of the brain with cognitive behavior therapy in patients with panic disorder

The Synergistic effect of repeated transcranial magnetic stimulation with cognitive behavioral therapy in patients with panic disorder

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20210611051543N1
Enrollment
45
Registered
2021-08-05
Start date
2021-07-13
Completion date
Unknown
Last updated
2021-08-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Panic disorder. Panic disorder [episodic paroxysmal anxiety] without agoraphobia

Interventions

Intervention 1: Intervention group: The combination of repetitive transcranial magnetic stimulation of the brain and cognitive-behavioral therapy? The first session of cognitive-behavioral therapy, in
session 2: assessment, socialization to treatment, medication and homework, session 3: assessment, interventions, medication and homework, session 4 includes assessment, behavioral interventions, med
sessions 5-8 include assessment, cognitive interventions, other interventions, medication and homework, sessions 9-10 include assessment, cognitive interventions, behavioral interventions, medication,
sessions 11-12 include assessment, cognitive interventions, behavioral interventions, other interventions, and homework. Repetitive transcranial magnetic stimulation protocol: 1 Hz transcranial magnet

Sponsors

Zanjan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Having diagnostic criteria for Panic disorder based on psychiatrist diagnosis and clinical interview Having at least a third secondary education Experience at least 3 panic attacks per week Being 18 to 65 years old Signing the written consent form Not to be exposed to any psychological Therapies for at least 1 month before entering the research Not using alcohol and substances during the last month

Exclusion criteria

Exclusion criteria: Inclusion complete criteria for personality disorder Existence of psychotic disorders, bipolar History of epilepsy and seizures No contraindications to repeated transcranial magnetic Stimulation, such as metal in the head or implanted brain medical Devices Diagnosis of any neurological conditions affecting central Nervous system(e.g. Parkinson's disease) Pregnancy Use of tricyclic antidepressants (TCAs)

Design outcomes

Primary

MeasureTime frame
Percentage of people whose Panic Disorder Severity Scale score is above 4. Timepoint: Measurement of panic before intervention, in the tenth session of the intervention, after the intervention, follow-up for two months after the intervention. Method of measurement: Panic Disorder Severity Scale.;Percentage of people whose Beck questionnaire score is above 20. Timepoint: Measurement of depression before the intervention, after intervention, tow-month follow-up intervention. Method of measurement: Beck Questionnaire.;Percentage of people whose Hamilton questionnaire score is above 17. Timepoint: Measurement of depression before the intervention, after intervention and tow-month follow-up intervention. Method of measurement: Hamilton Depression Test.;Cognitive test score in Stroop test. Timepoint: Measurement of attention bias before intervention, after intervention and tow-month follow-up after intervention. Method of measurement: Stroop test.;Analyze the electroencephalography results. Timepoint: Measurements before the intervention, after the intervention. Method of measurement: Electroencephalography.

Secondary

MeasureTime frame
The higher the score, the higher the emotion regulation. Timepoint: Measuring emotion regulation strategies before intervention, after intervention and follow-up for tow months after intervention. Method of measurement: Gross and John Emotion Regulation Questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Habibi

Zanjan University of Medical Sciences

93Ma.Hbi@zums.ac.ir+98 24 3354 4001

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026