Condition 1: Depressive Disorders. Condition 2: Epilepsy. Mood disorder due to known physiological condition with depressive features Epilepsy and recurrent seizures
Conditions
Interventions
Intervention 1: Intervention group 1: venlafaxine
Drug therapy started with 37.5 mg in the first week, reached 75 mg in the second week and finally reached 150 mg in the third week to the sixteenth week. Intervention 2: Intervention group 2: Sertrali
Drug therapy in this group starts with 25 mg in the first week, reaches 50 mg in the second week, and is finally 100 mg in the third week to the sixteenth week.
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Definite Diagnosis of Epilepsy based on Clinical Findings and Neurologist View Positive Evaluation of Depression based on NDDI-E Questionnaire Clinical Diagnosis of Moderate to Severe Depression Using Hamilton Depression Scale
Exclusion criteria
Exclusion criteria: Suicide Attempt in Recent Year Alcohol or Substance Abuse History of a Complex Mood Disorder e.g. Bipolar Disorder Other Accompanying Neurological Disease Evidence of Hypersensitivity to SSRIs Hypertension Major Kidney or Liver Dysfunction Active Hemorrhage Pregnancy and Breast-feeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The severity of depression in patients with epilepsy participating in the study according to the Hamilton scale. Timepoint: Depression severity at the beginning of the study (before the intervention), the third, eighth, and sixteenth weeks after the intervention is evaluated. Method of measurement: Hamilton depression clinical scale (HAM-D). | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of seizures that occur during the week (if any). Timepoint: At the beginning of the study (before the intervention) and then the third, eighth, and sixteenth week after the intervention. Method of measurement: Counting the number of seizures per week based on history.;Quality of Life in Epilepsy. Timepoint: Before initiating the therapy and after sixteen week of treatment. Method of measurement: Quality of Life in Epilepsy (31 Questions) Questionnaire.;Pharmacological side effects. Timepoint: In the first week and then the third and eighth after the intervention. Method of measurement: Based on the history and a prepared form of drug side effects. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSeyyed Reza Ebadi
Tehran University of Medical Sciences
Outcome results
None listed