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treatment for schizophrenia patients: double-blind randomized controlled trial study

The impact of prefrontal tRNS on schizophrenia clinical symptoms and cognitive deficits

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20210608051514N2
Enrollment
40
Registered
2021-10-08
Start date
2022-01-20
Completion date
Unknown
Last updated
2021-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Schizophrenia. Schizophrenia

Interventions

Intervention 1: The intervention group will receive random stimulation treatment with a frequency of 100_640 Hz, with an average of 1 mA and a range of 2 mA for 10 sessions of 20 minutes. Intervention

Sponsors

Zanjan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1- Having the ability of informed consent to participate in research 2_Have a minimum age of 18 and a maximum of 65 years 3_have a diagnosis of schizophrenia or schizoaffective disorder 4_ The same dose and drug used before the start and during the research 5_ Being right-handed 6_ Stabilization in drug treatment for at least 7 weeks

Exclusion criteria

Exclusion criteria: 1_Have a history of suicide and abuse of alcohol and substances other than caffeine and tobacco 2_Have a history of neurological diseases 3_Have a disease related to the scalp 4_Have a history of head trauma 5_ Existence of device or tool in the head 6- Leaving the research after being absent in two consecutive sessions 7- Pregnancy or breastfeeding

Design outcomes

Primary

MeasureTime frame
Negative symptoms:Theoretical definition: It is one of the clinical symptoms in schizophrenia that includes superficial emotion, poor speech, lack of motivation, unhappiness and social transgression.Operational definition: The score that a person gets from the positive and negative symptoms of schizophrenia.Positive symptoms: Theoretical definition includes delusions, delusions, disturbed speech, and disturbed behavior that persist throughout a one-month period.Operational definition: The score that a person gets from the positive and negative symptoms of schizophrenia. Timepoint: Pre-test-post-test-one-month follow-up-3 moth follow-up. Method of measurement: The score that a person gets from the questionnaire for measuring positive and negative symptoms in schizophrenia.

Secondary

MeasureTime frame
Working memory:Theoretical definition: means the ability to store and manipulate information in memory, which is an essential prerequisite for complex cognitive tasks such as learning, reasoning and comprehension. Timepoint: Pre-test-post-test-one-month follow-up_2 month follow-up. Method of measurement: The score that a person gets from the working memory test in the CANTAB collection.;Executive function: Theoretical definition: A general structure that encompasses a wide range of cognitive processes and behavioral abilities that include reasoning, problem solving, planning, organizing, working memory, ordering, the ability to pay constant attention, deal with interference, benefit from feedback, and practice. Includes multitasking. Timepoint: Pre-test-post-test-one-month follow-up_2 month follow-up. Method of measurement: The score that a person gets from the executive function measurement test in the CANTAB collection.;Emotion Recognition: A Theoretical DefinitionThe ability to recognize people's emotions through non-verbal expression such as face, voice, or gestures and body movements is a key ability in social interactions and a prerequisite for understanding and predicting and responding appropriately to one's behavior. Timepoint: Pre-test-post-test-one-month follow-up-two-month follow-up. Method of measurement: The score that a person gets from the emotional recognition test in the CANTAB collection.;DepressionTheoretical definition: Depression is a transient or long-term decline in mood. The main characteristic is the feeling of dissatisfaction, which means lack of interest or lack of feeling of pleasure for the activities that the person already enjoys. Timepoint: Pre-test-post-test-one-month follow-up_2 month follow-up. Method of measurement: A person's score on the Revised Depression Scale.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Mohsen Dadashi

Zanjan University of Medical Sciences

mohsen.dadashi@gmail.com+98 21 8670 5504

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026