The effect of colostrum on the short outcome of premature infants

To assess the efficacy of oropharyngeal colostrum therapy on short outcome among preterm neonates

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210607051507N2

Enrollment

126

Registered

2021-09-25

Start date

2021-10-02

Completion date

Unknown

Last updated

2024-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The effect of colostrum on the short-term prognosis of preterm infants. Preterm [premature] newborn [other]

Interventions

Intervention 1: Intervention group: 63 infants received 0.2 cc of their mother's colostrum via the oropharynx every 6 hours to 3 days from birth to the first 72 hours of birth. Intervention 2: Control

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Premature infants under 32 weeks of gestation Or below 1500 grams

Exclusion criteria

Exclusion criteria: Genetic and chromosomal abnormalities, HIV-positive mother, drug-addicted mother Any case where there is a limitation on milk usage for the baby

Design outcomes

Primary

Measure	Time frame
Clinical neonatal sepsis. Timepoint: Infant with clinical signs of sepsis diagnosed by a pediatrician. Method of measurement: Extract from file.;Brain hemorrhage. Timepoint: Brain sonography. Method of measurement: extract from file.;Bronchopulmonary dysplasia. Timepoint: Since the doctor's diagnosis and oxygen dependence. Method of measurement: Extract from file.;ROPs requiring laser surgery. Timepoint: Since the diagnosis of the eye to the doctor based on the need for laser surgery until 1 month old. Method of measurement: Extract from file.;Ventilator-associated pneumonia. Timepoint: Based on physician's diagnosis and radiographic findings. Method of measurement: Extract from file.;Duration of preterm neonatal hospitalization. Timepoint: From the time of birth and hospitalization to the time of discharge. Method of measurement: Extract from the file.;How long it takes for a baby to be fully breastfed. Timepoint: From the onset of colostrum to breastfeeding 150 cc per kilogram of body weight. Method of measurement: Extract from the file.;Necrotizing enterocolitis in preterm infants. Timepoint: Since diagnosis based on clinical and radiological and laboratory symptoms. Method of measurement: Extraction from the file and clinical signs and radiological evidence recorded in the file.;Death of neonate. Timepoint: If there is no response to resuscitation and cardio-respiratory arrest. Method of measurement: Extract from file.;Confirmed neonatal sepsis. Timepoint: Since the diagnosis of neonates with clinical signs of sepsis with positive culture. Method of measurement: Extract blood and crp culture tests from hospital records and electronic systems.	—

Measure

Time frame

Clinical neonatal sepsis. Timepoint: Infant with clinical signs of sepsis diagnosed by a pediatrician. Method of measurement: Extract from file.;Brain hemorrhage. Timepoint: Brain sonography. Method of measurement: extract from file.;Bronchopulmonary dysplasia. Timepoint: Since the doctor's diagnosis and oxygen dependence. Method of measurement: Extract from file.;ROPs requiring laser surgery. Timepoint: Since the diagnosis of the eye to the doctor based on the need for laser surgery until 1 month old. Method of measurement: Extract from file.;Ventilator-associated pneumonia. Timepoint: Based on physician's diagnosis and radiographic findings. Method of measurement: Extract from file.;Duration of preterm neonatal hospitalization. Timepoint: From the time of birth and hospitalization to the time of discharge. Method of measurement: Extract from the file.;How long it takes for a baby to be fully breastfed. Timepoint: From the onset of colostrum to breastfeeding 150 cc per kilogram of body weight. Method of measurement: Extract from the file.;Necrotizing enterocolitis in preterm infants. Timepoint: Since diagnosis based on clinical and radiological and laboratory symptoms. Method of measurement: Extraction from the file and clinical signs and radiological evidence recorded in the file.;Death of neonate. Timepoint: If there is no response to resuscitation and cardio-respiratory arrest. Method of measurement: Extract from file.;Confirmed neonatal sepsis. Timepoint: Since the diagnosis of neonates with clinical signs of sepsis with positive culture. Method of measurement: Extract blood and crp culture tests from hospital records and electronic systems.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAmeneh Lamsehchi

Hamedan University of Medical Sciences

lamsehchila@gmail.com+98 81 3827 7459

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026