Nasal intermittent positive pressure ventilation with nasal cannula vs. Nasal continuous positive airway pressure as respiratory support in the management of Transient Tachypnea of Newborn

Nasal intermittent positive pressure ventilation with nasal cannula vs. Nasal continuous positive airway pressure as respiratory support in the management of Transient Tachypnea of Newborn: A Randomized Control Trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210607051507N1

Enrollment

Registered

2021-07-01

Start date

2021-06-22

Completion date

Unknown

Last updated

2021-07-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Transient Tachypnea of Newborn. ?Intermittent Positive Pressure Ventilation , Nasal Continuous Positive Airway Pressure, Transient Tachypnea of Newborn

Interventions

Intervention 1: Intervention group:NIPPV may be applied by a facial mask or nasal cannula. In this study, we used a nasal cannula to deliver positive-pressure breathing by Drager (Babylog 8000 SC) ven

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: N eonates with TTN were identified with the criteria of Rawlings and Smith including 1.beginning of tachypnea within 6?h after birth; 2. tenacity of tachypnea for at least 12?h; 3.chest radiograph compatible with TTN 4. exclusion of other known respiratory disorders and non-respiratory disorders likely to cause the same features. Clinical features are consist of tachypnea (respiratory rate more than 60) with or without cyanosis, signs of distress (nasal ?aring, grunting, and retraction). Radiographic signs may include at least one of these; lung hyper in?ation, perihilar congestion or streaking, ?uid ?lled interlobar ?ssure, bilateral in?ltration, pulmonary edema. All of the neonates were born 37 weeks and older.

Exclusion criteria

Exclusion criteria: neonate delivered less than 37 weeks, significant chromosomal abnormalities, meconium aspiration signs, asphyxia, a newborn baby with a metabolic disorder, congenital heart disease (diagnosed with echocardiography), persistent pulmonary hypertension of neonate, RDS, Pneumonia, and requirement of more than 40 percent FiO2. We excluded neonates who had positive CRP or positive Blood culture or if chest x rays matched with the diagnosis of pneumonia.

Design outcomes

Primary

Measure	Time frame
Oxygen consumption. Timepoint: 24 hours of birth. Method of measurement: CPAP .NIPPV.;The duration of respiratory support. Timepoint: during hospitalization. Method of measurement: due to records patients file.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSetareh Sagheb

Tehran University of Medical Sciences

dr.ssagheb@yahoo.com+98 21 8490 1000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026