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Effect of transcranial direct current stimulation in patients with chronic ankle instability

Effect of balance training combined with transcranial direct current stimulation on preparatory brain activity in patients with chronic ankle instability

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20210604051488N1
Enrollment
46
Registered
2021-06-28
Start date
2021-07-06
Completion date
Unknown
Last updated
2021-07-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic ankle instability. Sprain of ankle

Interventions

Intervention 1: Intervention group: Participants give 4-wk intervention of anodal transcranial direct current stimulation (aTDCS) with balance exercise. The exercises consist of Gastrocnemius and Sole
strengthening involved Thera-Band resistance Dorsiflexion, Plantar flexion, Inversion, Eversion
Neuromuscular control exercises involved Single-limb stance while kicking and single-limb–stance activities with eyes open and closed and Single-limb stance with ball toss
Progressive Balance Program consist of single-limb hops to stabilization ,hop to stabilization and reach. Exercises have difficulty levels and progress. Anodal transcranial direct current stimulation
Neuromuscular control ex

Sponsors

Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 35 Years

Inclusion criteria

Inclusion criteria: The initial unilateral ankle sprain must have occurred at least 12 months prior to study enrollment The most recent injury must have occurred more than 3 months prior to study enrollment Episodes of giving way or feeling of instability in the involved ankle History of inflammation symptoms such as swelling, weakness, pain within the past year Cumberland Ankle Instability Tool (CAIT) score less than 24 Acquiring a score < 90% in daily living activities and < 80% in sport activities from foot and ankle ability measure (FAAM) questionnaire People in the age range of 18 to 35 years

Exclusion criteria

Exclusion criteria: Evidence of neurological or psychiatric disorders, seizure and epilepsy, had a head injury resulting in a loss of consciousness, history of migraines History of ankle and lower limb surgery or fracture Pregnant Have any metallic implants, including intracranial electrodes,surgical clips, shrapnel or pacemaker

Design outcomes

Primary

MeasureTime frame
Beta event-related desynchronization (ERD) ; ERD is actually the frequency reduction in the beta and alpha bands, which begins about 2 to 1.5 seconds before the start of motion. The value of ERD at alpha and beta frequencies expresses the degree of cortical excitability. The larger the beta / alpha ERD, the higher the cortical excitability. In fact, ERD reflects the activity of motor areas along with the weakening of sensory afferents during movement. Alpha and beta band activity demonstrates brain preparation and brain planning. Timepoint: In the first evaluation session (before the intervention) and 48 hours after the last treatment session. Method of measurement: Using a 64-channel electroencephalography device (Micromed).;Peak Amplitude of Contingent Negative Variation (CNV) ; CNV is an event-dependent potential that is recorded using the warning-stimulus-response-motor response paradigm. In fact, CNV is a slow negative shift in the electroencephalographic wave amplitude between the two warning stimuli and the response stimulus, which is calculated by averaging the electroencephalographic wave in the time interval between the warning stimulus and the response stimulus. Timepoint: In the first evaluation session (before the intervention) and 48 hours after the last treatment session. Method of measurement: Using a 64-channel electroencephalography device(Micromed).;Time of Peak Amplitude of CNV; CNV is an event-dependent potential that is recorded using the warning-stimulus-response-motor response paradigm. In fact, CNV is a slow negative shift in the electroencephalographic wave amplitude between the two warning stimuli and the response stimulus, which is calculated by averaging the electroencephalographic wave in the time interval between the warning stimulus and the response stimulus. Timepoint: In the first evaluation session (before the intervention) and 48 hours after the last treatment session. Method of measurement: Using a 64-channel electroencephalograp

Secondary

MeasureTime frame
Star Excursion Balance Test ; This test is used for clinical evaluation. In other words, the maximum range of motion of the person standing on one leg stimulates the opposite leg in the posterolateral, posteromedial, and anterior direction. Timepoint: In the first evaluation session (before the intervention) and 48 hours after the last treatment session. Method of measurement: Strip Meter.;The foot and ankle ability measure questionnaire (FAAM) score ; This questionnaire consists of 29 questions that are divided into two parts ADL and Sport, which includes 21 and 8 items, respectively, and 5 answers are considered for each question and its total score is reported as a percentage. The higher percentage show higher performance. Timepoint: In the first evaluation session (before the intervention) and 48 hours after the last treatment session. Method of measurement: The foot and ankle ability measure questionnaire (FAAM).;The Cumberland Ankle Instability Tool's score; This questionnaire consists of 9 questions, the total score of which is 30, which indicates a high stability in the ankle. The Persian version of the Cumberland Ankle Instability Questionnaire can be used as a reliable tool to diagnose instability and measure changes due to therapeutic interventions in athletes with functional ankle instability. Timepoint: In the first evaluation session (before the intervention) and 48 hours after the last treatment session. Method of measurement: The Cumberland Ankle Instability Tool.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactRoya Khanmohammadi

Tehran University of Medical Sciences

Rkhanmohammadi@sina.tums.ac.ir+98 21 7753 4133

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 5, 2026