Non-alcoholic fatty liver. Fatty (change of) liver, not elsewhere classified
Conditions
Interventions
Intervention 1: Intervention group: Patients in this group will receive myo-inositol supplement and nutritional recommendation for 8 weeks. Two 2 gr sachet of myo-inositol powder will be asked to be d
Sponsors
Qazvin University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: Age 18-55 years Body mass index = 30-40 Kg /m2 Willingness to cooperate Hepatic steatosis based on Grade 1 and 2 NAFLD disease
Exclusion criteria
Exclusion criteria: Athlete, pregnancy, lactation and menopause in women Smoking and drinking alcohol Adherence to a special diet or weight loss 3 months before the study Use of chemical or herbal medicines for weight loss, hepatotoxic (phenytoin, amoxifine, lithium), lipid-lowering (statins), Insulin sensitizer, corticosteroids and non-steroidal, anti-inflammatory medications and any dietary supplements for 3 months before the study History of weight loss surgery over the last year those with cardiovascular, hepatic, renal, intestinal, thyroid and parathyroid dysfunction, billiary, any known autoimmune diseases, PCOs, cancers and conditions with mal-absorption such as Sprue and Crohn Candidate or history of Liver transplant
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum leptin. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: ELISA method.;Serum adiponectin. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: ELISA method.;Ratio of leptin to adiponectin. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: According to the formula.;Pro-oxidant Antioxidant Balance (PAB). Timepoint: Baseline and 8 weeks after intervention. Method of measurement: Enzymatic and chemical methods.;Body mass index (BMI). Timepoint: Baseline and 8 weeks after intervention. Method of measurement: According to the formula.;Fat mass. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: Using bioelectric impedance analyzer.;Energy, macronutrients and micronutrients intakes. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: a 3-days 24 hour- recall questionnaire at each phase will be completed and analyzed using Nutritionist 4 software.;Physical activity level. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: Via short form of IPAQ questionnaire.;Appetite status. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: Validated appetite questionnaire.;Weight. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: using Seca scale.;Fat Free mass. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: Using body analyzer based on bioelectric impedance. | — |
Secondary
| Measure | Time frame |
|---|---|
| Fatty liver grade. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: Ultrasonigraphy.;Alanine aminotransferase (ALT). Timepoint: Baseline and 8 weeks after intervention. Method of measurement: enzymatic method.;Aspartate aminotransferase (AST). Timepoint: Baseline and 8 weeks after intervention. Method of measurement: enzymatic method. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammad Reza Shiri Shahsavar
Qazvin University of Medical Sciences
Outcome results
None listed