intracerebral hemorrhage. Nontraumatic intracerebral hemorrhage
Conditions
Interventions
Intervention 1: Intervention group: In patients allocated to the experimental group, the overall treatment principle is to apply sufficient morphine: morphine will be administered by 3 mg IV infusion
Sponsors
Zanjan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Acute stroke syndrome due to spontaneous ICH, which is defined as the sudden occurrence of bleeding into the parenchyma of the brain that may extend into the ventricles or subarachnoid space as confirmed by a clinical history and computed tomography (CT) scan Systolic BP =?150 mmHg at least twice (based on brachial artery pressure measured in the upper arm in two measurements conducted =?2 min apart) Age?>?18 years Feasible for emergency antihypertensive treatment and real-time BP monitoring Symptom onset within 24 h (if the time of onset is unknown, the last known time is selected) Special care unit (SCU) or stroke unit admission within 24 h
Exclusion criteria
Exclusion criteria: Subjects with contraindications for emergency-intensified antihypertensive treatment (such as severe carotid, vertebral or cerebral artery stenosis, known Moyamoya disease or multiple arteritis, and severe aortic stenosis or severe kidney failure) Intracranial hemorrhage secondary to intracranial tumor, recent trauma, cerebral infarction and thrombolytic therapy History of ischemic stroke within 30 days before disease onset The presence of dementia (previously diagnosed by a medical institution) or significant post-stroke disability (modified Rankin Scale (mRS) =?3 points [32]) pregnancy or lactating
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood pressure control. Timepoint: Blood pressure will be controlled every 15 minutes for 2 hours at the start of treatment, then every 30 minutes for 6 hours, then every 1 hour for 16 hours, and then every 6 hours for a week. Method of measurement: Physical examination.;National Institutes of Health Stroke Scale (NIHSS) score. Timepoint: At Admission, 24 hours later and at discharge. Method of measurement: Physical Examination.;Modified Rankin Scale (MRS) score. Timepoint: At admission and 3 months after discharge. Method of measurement: Questionnaire.;Mortality. Timepoint: In-hospital and during 3 months after discharge. Method of measurement: Medical records and follow up information. | — |
Secondary
| Measure | Time frame |
|---|---|
| Mechanical ventilation rate. Timepoint: Within 2 days of hospitalization. Method of measurement: Clinical assessment. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAbdoreza Ghoreshi
Zanjan University of Medical Sciences
Outcome results
None listed