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Effect of melatonin in treatment of schizophrenia

Evaluating the effect of melatonin on positive and negative symptoms of schizophrenic patients admitted to psychiatry ward of Golestan hospital in 2021-2022

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20210528051416N1
Enrollment
46
Registered
2021-06-21
Start date
2021-06-22
Completion date
Unknown
Last updated
2021-07-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

schizophrenia. Schizophrenia

Interventions

Intervention 1: Intervention group: patients will be treated with melatonin tablet (3 mg) which is prepared in RAZAK drug company. The intervention group will receive two melatonin tablets 3 mg (6 mg

Sponsors

Ahvaz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients who have admitted in psychiatry ward of Golestan hospital Age 18-65 years Schizophrenic patient according to DSM-5 Satisfaction of patients' guardianship Schizophrenic patients who have treated with risperidone

Exclusion criteria

Exclusion criteria: Treatment with any psych medications except for risperidone Comorbidity of other psychopathologies Abuse of any substance, drug, or alcohol Drug reaction to melatonin or placebo Past history of treatment with clozapine or melatonin Pregnancy, mental retardation or any other neurologic and neurocognitive disorders, sleep apnea Proven depression according to Calgary scale Treatment with ECT in the current episode

Design outcomes

Primary

MeasureTime frame
Score of positive and negative symptoms according to PANSS scale. Timepoint: At the start of intervention, 3 weeks and 6 weeks later. Method of measurement: positive and negative syndrome scale.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSanam Anoosheh

Ahvaz University of Medical Sciences

anoosheh.sanam@icloud.com+98 61 3374 3038

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026