burn. Burn and corrosion of head, face, and neck
Conditions
Interventions
Intervention 1: Intervention group: Intervention group: Intervention group: Patients receiving estradiol valerate upon arrival after receiving consent, standard treatment and single dose of estradiol
Sponsors
Rasht University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Patient with severe burns (second or higher degree burns with an area of more than 20%) Fill out the informed consent form Acute burns have occurred in less than 24 hours.
Exclusion criteria
Exclusion criteria: Electric burns Inhalation burns People with a history of estrogen-dependent cancer (breast, uterus, ovary) Pregnant and lactating people taking phenobarbital, carbamazepine, ritonavir, rifampin, People with a history of thrombophlebitis and thromboembolism.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Discharge time and speed of recovery. Timepoint: daily. Method of measurement: Based on patients' records. | — |
Secondary
| Measure | Time frame |
|---|---|
| Discharge status. Timepoint: daily. Method of measurement: view of patient file.;Duration of hospitalization in the ICU. Timepoint: daily. Method of measurement: patient record.;Comparison of changes in inflammatory factor IL-6. Timepoint: on day 1 (before injection of estradiol valerate) and 3 and 7. Method of measurement: ELISA.;Itching rate. Timepoint: daily. Method of measurement: based on the patient's statements.;Comparison of changes in laboratory indices of serum levels of CRP, ferritin, LDH, CPK. Timepoint: On days 1, 3 and 7. Method of measurement: By laboratory kits.;INR, PT, PTT. Timepoint: On days 1, 3 and 7. Method of measurement: By laboratory kits.;Serum and blood transfusion. Timepoint: daily. Method of measurement: based on patient records. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammad Reza Mobayen
Rasht University of Medical Sciences
Outcome results
None listed