Burn. Burn and corrosion of head, face, and neck
Conditions
Interventions
Intervention 1: Intervention group: The treatment with oral ranolazine 500 mg tablets for patients in the intervention group will be started in the emergency room in such a way that the maximum time i
Sponsors
Rasht University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Age range from 18 to 65 years Acute burn in less than 6 hours Total body surface area (TBSA) between 20 - 50% patients of American Society of Anesthesiologists (ASA) class I (a normal healthy person) Fill out the informed consent
Exclusion criteria
Exclusion criteria: Having severe hypertension blood pressure (BP) = 160/90 mmHg or systolic pressure below 100 mmHg Ischemic changes in electrocardiogram (ECG) Heart rate less than 70 beats per minute Pregnant women Peripheral vascular disease Presence of inhalation injury Presence of burn shock (including decreased cardiac output, increased vascular resistance, hypovolemia and hypoperfusion following severe burns) Electrical and chemical burns Kidney or liver failure caused by burns (according to the kidney and liver metabolism of the drug) Presence of drug interactions with the patient's previous medications
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Graft to TBSA (total body surface area) percent ratio. Timepoint: At discharge. Method of measurement: Measurements based on Wallace criteria.;Mortality. Timepoint: At discharge. Method of measurement: Based on the clinical outcome recorded in the patients' files. | — |
Secondary
| Measure | Time frame |
|---|---|
| Length of hospital stay. Timepoint: At discharge. Method of measurement: Based on patient's file.;SIRS (Systemic inflammatory response syndrome). Timepoint: On the 1st, 3rd and 7th days of hospitalization. Method of measurement: Based on criteria including temperature, heart rate, respiratory rate, and WBC (white blood cell) count.;Infection. Timepoint: On the 1st, 3rd and 7th days of hospitalization. Method of measurement: Based on clinical decision of doctor. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Mohammad Reza Mobayen
Rasht University of Medical Sciences
Outcome results
None listed