Caffeine pills in the prevention of postoperative delirium

Comparison of the effect of oral caffeine pills compared to placebo in the prevention of postoprative delirium in surgical patients admitted to intensive care unit.

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210523051374N1

Enrollment

100

Registered

2024-07-26

Start date

2024-06-03

Completion date

Unknown

Last updated

2024-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Delirium. Delirium due to known physiological condition

Interventions

Intervention 1: Intervention group: Caffeine group 200 mg each 12 hours for 5 days, Karen Pharmaceutical Company. Intervention 2: Control group: Placebo group 1pill each 12 hours for 5 days, Karen Pha

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Age between 18 and 75 years Postoperative surgical ICU patients (major surgeries: abdominal surgery and urology orthopedics) Patient consent to participate in the study

Exclusion criteria

Exclusion criteria: Patients with known arrhythmia Patients with advanced liver and kidney failure Burn and trauma cases and heart surgery patients Pregnancy Morbid obese patients (body mass index greater than 40 or weight greater than 130 kg) Patients with known seizures

Design outcomes

Primary

Measure	Time frame
Delirium. Timepoint: 3 days post-ICU admission. Method of measurement: Confusion assessment method for ICU (CAM-ICU).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactBabak Moayer

Tehran University of Medical Sciences

moayer-b@razi.tums.ac.ir+98 21 6634 8523

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026