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The effect of pomegranate peel extract on the prevention of ventilator-associated pneumonia

The comparative effects of mouthwash containing pomegranate peel extract (Punica granatum) and chlorhexidin 0.2% on the prevention of ventilator associated pneumonia in patients admitted to intensive care units

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20210523051370N4
Enrollment
120
Registered
2021-10-12
Start date
2021-11-22
Completion date
Unknown
Last updated
2021-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ventilator-associated pneumonia. ventilator-associated pneumonia

Interventions

Intervention 1: Before using mouthwash, the pneumonia is assessed using the Clinical Pulmonary Infection Score (CPIS). To apply the mouthwash in the experimental and control groups, the researcher wil

Sponsors

Mazandaran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients aged 18-65 years Having a tracheal tube Up to 12 hours to elapse after ICU admission Not affected by immune system disorders or lung diseases, including pneumonia, asthma, and allergic rhinitis Having natural teeth Not simultaneously participating in other interventional studies

Exclusion criteria

Exclusion criteria: Patients with tracheostomy tube A history of taking antibiotics during the last two weeks A history of allergy to chlorhexidine and herbal mouthwashes Reintubation Severe maxillofacial trauma Pregnant and lactating patients A history of malignancy and cancer A history of head and neck radiotherapy A history of oral mucositis and periodontal diseases Patients with sepsis and COVID-19 in admission Patients with COVID-19 in admission

Design outcomes

Primary

MeasureTime frame
Clinical Pulmonary Infection Score. According to the CPIS, a score of 6 or higher indicates mechanical ventilator-associated pneumonia. Timepoint: The assessor will check and record the Clinical Pulmonary Infection Score of all patients on first, third and fifth days. Method of measurement: Pulmonary of Infection Survey Questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Seyed Afshin Shorofi

Mazandaran University of Medical Sciences

ashorofi@yahoo.com+98 11 3336 7342

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026