H. pylori infection. Helicobacter pylori [H. pylori] as the cause of diseases classified elsewhere
Conditions
Interventions
Intervention 1: High dose group: Patients receive amoxicillin 1 gr tds, bismuth 240 mg tds and omeprazole 40 mg bid for 14 days. Intervention 2: Medium dose group: Patients receive amoxicillin 750 mg
Sponsors
Mazandaran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients have H. pylori eradication indication based on endoscopic evidence Patients with positive Rapid urease test Patients with positive histology of H. pylori infection
Exclusion criteria
Exclusion criteria: Age under 18 years Reluctance to participate in the study Pregnancy and lactation Patients taking concomitant anticoagulants, corticosteroids or ketoconazole. Patients with a history of gastric surgery Patients with a history of heart failure, lung disease, chronic kidney failure, liver disease (cirrhosis or chronic hepatitis for any reason), or a history of cancer Consumption of alcohol in any amount The presence of any type of malignancy History of drug allergy to the drugs in this study History of H. pylori eradication regimens at any time before this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| H. pylori eradication. Timepoint: At least the eighth week after starting treatment. Method of measurement: stool examination. | — |
Secondary
| Measure | Time frame |
|---|---|
| Drug compliance rate. Timepoint: 8th week of study. Method of measurement: questionnaire.;Severity of drug side effects. Timepoint: 8th week of study. Method of measurement: questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHafez Tirgar Fakheri
Mazandaran University of Medical Sciences
Outcome results
None listed