Effect of Angiotensin-converting enzyme and ß-blockers on the prognosis of severe isolated brain trauma

Effect of Angiotensin-converting enzyme and ß-blockers on the prognosis of patients with severely isolated brain trauma

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210514051289N1

Enrollment

Registered

2022-05-08

Start date

2021-11-22

Completion date

Unknown

Last updated

2022-05-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Severe isolated brain trauma. Diffuse traumatic brain injury

Interventions

Intervention 1: Intervention group1: Propranolol From abidi Pharmacy: The dose of 1 mg, injectable, starts in the first 24 hours after admission for patients in this group and continues until two week

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Severe trauma Age greater than or equal to 18 years No previous use of beta-blockers or Angiotensin-converting enzyme at home Informed consent of the patient's guardian or legal guardian to admit the patient to the study

Exclusion criteria

Exclusion criteria: Renal artery stenosis Chronic kidney disease History of drug allergy Hyperkalemia High creatinine Bradycardia or heart block

Design outcomes

Primary

Measure	Time frame
Glasgow Outcome Score. Timepoint: Three months after the intervention. Method of measurement: Glasgow Outcome Scale to measure level of consciousness.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMehdi Mahmoudkhani

Esfahan University of Medical Sciences

mahmoodkhani@med.mui.ac.ir+98 31 3668 0048

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026