Evaluation of the effects of calcium supplementation alone and with calcitriol in preventing the symptoms of hypocalcemia following total or near total thyroidectomy

Evaluation of the prophylactic effects of oral calcium supplement alone and with calcitriol in the development of symptomatic hypocalcemia after total or near-total thyroidectomy

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210513051285N1

Enrollment

100

Registered

2022-02-24

Start date

2021-02-08

Completion date

Unknown

Last updated

2022-03-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Symptomatic hypocalcemia after total or near-total thyroidectomy. Postprocedural endocrine and metabolic complications and disorders, not elsewhere classified

Interventions

Intervention 1: Control group: Calcium will only be given if hypocalcemia occurs. Intervention 2: Intervention group: About 12 hours after surgery, when the patient is able to tolerate orally, calcium

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: In this study, patients who are candidates for surgery and removal of both thyroid lobes total or near-total due to multinodular goiter or thyroid cancer will be selected.

Exclusion criteria

Exclusion criteria: Patients with preoperative hypocalcemia Patients with intraoperative parathyroid injury (mentioned by the surgeon , autograft and ischemic symptoms), Presence of parathyroid adenoma before or after surgery or any underlying disease that impairs parathyroid hormone, vitamin D, calcium, and albumin levels (such as chronic kidney disease or known diseases of malabsorption and indigestion) , Patients who have undergone extensive cervical lymphadenectomy during thyroidectomy, Patients with hypercalcemia and hypercalciuria, patients with calcium kidney stones, ventricular fibrillation, digoxin toxicity, sarcoidosis and Vit D poisoning. Patient dissatisfaction with participating in this study The presence of a previous major procedure (such as total laryngectomy and parathyroidectomy), receiving prophylactic medication for osteoporosis (including calcium and vitamin D supplementation).

Design outcomes

Primary

Measure	Time frame
Serum calcium level. Timepoint: Before surgery, 6 to 12 hours after surgery, 18 to 24 hours after surgery, 48 to 72 hours after surgery, next in case of recurrence of hypocalcemia and discharge time. Method of measurement: Based on laboratory tests.	—

Secondary

Measure	Time frame
Clinical signs of calcium deficiency. Timepoint: Every 2 hours. Method of measurement: History and examination.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAmir Alizadeh

Tabriz University of Medical Sciences

amir313.alizadeh@gmail.com+98 41 3337 3920

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026