Evaluation of the expanded conjunctiva in pterygium surgery

Pterygium surgery by using autologous conjunctival cells transplantation implanted on human amniotic membrane

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210513051283N1

Enrollment

Registered

2021-08-15

Start date

2021-09-23

Completion date

Unknown

Last updated

2021-08-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

primary pterygium-. Pterygium of eye

Interventions

Intervention group: We will get a sample of conjuctiva, 2x1 mm, from inferior fornix of the eye with pterygium two weeks before operation. After isolation the epithelium from tenon layer, the sample w

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: presence the primary pterygium

Exclusion criteria

Exclusion criteria: ?Dissatisfaction patients

Design outcomes

Primary

Measure	Time frame
Evaluation of re-epithelialization of cultivated tissue. Timepoint: Before conjunctival transplantation. Method of measurement: Hematoxilin-eosin staining.;Evaluation of collagenesis. Timepoint: Before conjunctival transplantation. Method of measurement: Trichrome-mason staining.;Evaluation of re-epithelialization and collagenesis of cultivated tissue. Timepoint: Before conjunctival transplantation. Method of measurement: Expression of integrin B 1,MUC4,CX43,Oct4,p63,CK19,CK13,CK12,CK3 by RT-PCR.;Healing process of transplanted conjunctiva. Timepoint: Day 1,3,7 and months 1,3,6,12. Method of measurement: Examination and Fluorescin staining.	—

Measure

Time frame

Evaluation of re-epithelialization of cultivated tissue. Timepoint: Before conjunctival transplantation. Method of measurement: Hematoxilin-eosin staining.;Evaluation of collagenesis. Timepoint: Before conjunctival transplantation. Method of measurement: Trichrome-mason staining.;Evaluation of re-epithelialization and collagenesis of cultivated tissue. Timepoint: Before conjunctival transplantation. Method of measurement: Expression of integrin B 1,MUC4,CX43,Oct4,p63,CK19,CK13,CK12,CK3 by RT-PCR.;Healing process of transplanted conjunctiva. Timepoint: Day 1,3,7 and months 1,3,6,12. Method of measurement: Examination and Fluorescin staining.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactHossein Aghaei

Iran University of Medical Sciences

aghaei.h@iums.ac.ir+98 21 6650 9162

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026