Recurrent implantation failure.
Conditions
Interventions
Intervention 1: Intervention group: intervention type: A single dose of in utero infusion of allogeneic in vitro decidualized menstrual blood stem cells with final volume of 0.5 ml containing 1 millio
Sponsors
Iranian academic center for education culture and research
Eligibility
Sex/Gender
Female
Age
20 Years to 37 Years
Inclusion criteria
Inclusion criteria: Women with recurrent implantation failure (Three unsuccessful embryo transfer cycles with transfer of at least one blast stage or one cleavage stage A in each cycle) No history of previous pregnancy FSH level of less than 10 mIU/mL Negative results for HIV, HBS Ag, HCV and VDRL
Exclusion criteria
Exclusion criteria: Hydrosalpinx Stage 3 or 4 endometriosis Asherman's syndrome Endometrial organic disease Chromosomal abnormalities in parents Spermogram abnormalities (DFI more than 30 and Normal sperm morphology less than 2% PCO with metabolic syndrome Anti-phospholipid antibodies Autoimmune diseases including rheumatoid arthritis, thyroid autoimmunity, lupus History of cancer, chemotherapy or radiotherapy Thin endometrium History of immunosuppressive drug intake during the past three months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Implantation rate. Timepoint: 2 weeks after embryo transfer. Method of measurement: Measurement of B-HCG. | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical pregnancy rate. Timepoint: 6 weeks after embryo transfer. Method of measurement: Sonography.;Live birth rate. Timepoint: At the end of pregnancy period. Method of measurement: Parturition.;Twin pregnancy. Timepoint: 6 weeks after embryo transfer. Method of measurement: Sonography.;Newborn weight. Timepoint: After delivery. Method of measurement: Weighting. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAmir-Hassan Zarnani
Iranian academic center for education culture and research
Outcome results
None listed