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The effect of acetaminophen on propofol injection pain

The effect of premedication with oral acetaminophen on the prevention of localized pain from intravenous injection of propofol as induction agent in patients under general anesthesia

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20210511051268N1
Enrollment
150
Registered
2021-05-13
Start date
2021-06-22
Completion date
Unknown
Last updated
2021-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Local Pain due to intravenous injection of propofol. Pain in unspecified hand

Interventions

Intervention 1: Intervention group: P500 group (patients with 500 mg of oral paracetamol) will receive medication 1 hour before transfer to the operating room. Each patient receives 1 placebo tablet a

Sponsors

Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: All patients for whom propofol is used as an induction of anesthesia

Exclusion criteria

Exclusion criteria: Weight less than 50 kg Chronic pain in any area of ??the body High blood pressure Cardiovascular disease Cerebrovascular disease Difficulty communicating (even if there is a marked drop in level of consciousness with the initial injection dose) Cirrhosis Abnormal liver function test results (AST and ALT more than twice normal) Kidney failure or creatinine clearance greater than 1.2 Allergy to acetaminophen Allergy to propofol Patients in whom propofol is not used to induce anesthesia Those who do not have a venous catheter in the back of the hand Those whose catheter size is not 20G those for whom we have to use rapid sequence induction for their anesthesia

Design outcomes

Primary

MeasureTime frame
11-point verbal numerical rating score (VNRS) for pain caused by propofol injection. Timepoint: Measuring the amount of pain right after injecting a quarter of the induction dose. Method of measurement: 11-Point Verbal Numerical Ranking (VNRS).

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSeyed Mohsen Mousavi

Tehran University of Medical Sciences

sm.mousavi.md.anesthesiology@gmail.com+98 21 8836 3149

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026