Comparison of the effect of two types of intra-articular knee injections

Comparison of the effect of two types of intra-articular injections including hyaluronic acid and corticosteroids in patients with mild to moderate knee osteoarthritis

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210511051258N1

Enrollment

Registered

2022-02-13

Start date

2021-07-10

Completion date

Unknown

Last updated

2022-03-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis. Osteoarthritis of knee

Interventions

Intervention 1: Intervention group: Injection of hyaluronic acid into the knee joint. Hyaluronic acid will be high molecular weight and will be injected once. The hyaluronic acid used will be of Iran

Eligibility

Sex/Gender

All

Age

50 Years to 70 Years

Inclusion criteria

Inclusion criteria: Be between 50 and 70 years old. Have a visual acuity scale (VAS) score greater than 4 in the knee joint at the start of treatment. Absence of inflammatory joint disease Proof of osteoarthritis in patients with a WOMAC score of at least 60 out of 96

Exclusion criteria

Exclusion criteria: Withdraw from the study Existence of severe cardiovascular diseases Existence of active infection and immune disorders People who are very young People with chronic diseases such as diabetes and hypertension, secondary osteoarthritis, systemic disorders, coagulopathies

Design outcomes

Primary

Measure	Time frame
The amount of pain in the knee joints. Timepoint: Visual analog scale score measurement at the beginning of the study and 6 weeks later. Method of measurement: visual analog scale.;Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC). Timepoint: WOMAC score set at the beginning of the study and 6 weeks later. Method of measurement: Western Ontario and McMaster Universities Osteoarthritis Index questionnaire (WOMAC).	—

Measure

Time frame

The amount of pain in the knee joints. Timepoint: Visual analog scale score measurement at the beginning of the study and 6 weeks later. Method of measurement: visual analog scale.;Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC). Timepoint: WOMAC score set at the beginning of the study and 6 weeks later. Method of measurement: Western Ontario and McMaster Universities Osteoarthritis Index questionnaire (WOMAC).

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Secondary

Measure	Time frame
Pain intensity score. Timepoint: Pain intensity measurement at the beginning of the study and 6 weeks later. Method of measurement: Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC).;Intensity of joint stiffness. Timepoint: Measurement of joint stiffness at the beginning of the study and 6 weeks later. Method of measurement: Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC).;Ability to perform daily activities score. Timepoint: Scoring the ability to perform daily activities at the beginning of the study and 6 weeks later. Method of measurement: Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC).	—

Measure

Time frame

Pain intensity score. Timepoint: Pain intensity measurement at the beginning of the study and 6 weeks later. Method of measurement: Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC).;Intensity of joint stiffness. Timepoint: Measurement of joint stiffness at the beginning of the study and 6 weeks later. Method of measurement: Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC).;Ability to perform daily activities score. Timepoint: Scoring the ability to perform daily activities at the beginning of the study and 6 weeks later. Method of measurement: Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC).

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSeyed Alireza ghoreishi

Birjand University of Medical Sciences

alireza.ghoreishi@bums.ac.ir098 56 32395000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026