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Comparison of collagen and dermal matrix in soft tissue thickening

Clinical and histological comparison of collagen membrane and acellular dermal matrix in peri_implant vertical soft tissue thickening

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20210510051251N1
Enrollment
24
Registered
2021-11-21
Start date
2021-10-12
Completion date
Unknown
Last updated
2021-11-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thin peri-implant soft tissue thickness.

Interventions

Intervention 1: Collagen membrane group: The membranes are 15 x 20 mm in size and are shaped according to the implant site to prevent the adjacent teeth from invading and to adapt to the newly placed

Sponsors

Islamic Azad University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to No maximum

Inclusion criteria

Inclusion criteria: Thin vertical sot tissue thickness(less than 2 mm) 4 mm keratinized tissue at least Partial edentulus in posterior of jaws Healthy soft tissue

Exclusion criteria

Exclusion criteria: Need to bone augmentation procedure O’ LEARY plaque index more than 20% Tobacco consumption Systemic disease related to soft & hard tissue healing Drug consumption related to soft & hard tissue healing Pregnancy

Design outcomes

Primary

MeasureTime frame
Soft tissue thickness. Timepoint: Base line, 2 months. Method of measurement: The thickness of the soft tissue in the center of the implant will be measured with a UNC periodontal probe (Hu-Friedy, USA) relying on the lingual flap.;Amount of collagen. Timepoint: Base line, 2 months. Method of measurement: The biopsy specimens will be placed in paraffin blocks after fixation and microscopic incisions 3-4 mm thick will be prepared. The prepared sections will then be stained with Masson trichrom to evaluate the amount of collagen.;Inflammation rate. Timepoint: Base line, 2 months. Method of measurement: Biopsy specimens are stained with hematoxylin-eosin to measure the severity of inflammation and will be classified to mild, moderate, and severe.;Vascular density. Timepoint: Base line, 2 months. Method of measurement: Immunohistochemical staining with CD34 monoclonal antibody prepared from mice will be used to evaluate blood vessels.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Nima Nadafpour

Islamic Azad University

nima.na04@gmail.com+98 21 2245 4571

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026