Comparing the effects of mannitol and hypertonic saline on blood coagulation in brain tumor patients

Investigating the effects of the simultaneous use of Voluven (hydroxyethyl starch 0.4.130) plus 20% mannitol compared to Voluven plus 3% hypertonic saline on blood coagulation using PFA-100 in patients who are candidates for surgery for supratentorial brain tumors.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210506051200N2

Enrollment

Registered

2023-04-05

Start date

2022-12-31

Completion date

Unknown

Last updated

2023-05-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Supratentorial tumor. Neoplasm of uncertain behavior of brain, supratentorial

Interventions

Intervention 1: Intervention group: In the mannitol (M) group, the initial blood sample is sent before anesthesia and then after 20 minutes of mannitol injection for PFA-100 measurement. Intervention

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Consent to study Age above 18 years

Exclusion criteria

Exclusion criteria: Absence of heart failure History of diseases affecting coagulation Recent use of drugs affecting coagulation Absence of renal failure Absence of liver failure

Design outcomes

Primary

Measure	Time frame
Closing time. Timepoint: Twenty minutes after drug injection in each of the two groups. Method of measurement: Using PFA100 laboratory test.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSohrab Salimi

Shahid Beheshti University of Medical Sciences

ssalimi@sbmu.ac.ir+98 21 2221 2058

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026