Comparison between effects of intravenous infusion Ibuprofen vs Morphine – Paracetamol on blood Platelet function

Comparison between effects of intravenous infusion Ibuprofen vs Morphine – Paracetamol on Platelet function in patients under supratentorial brain lesions resection

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210506051200N1

Enrollment

Registered

2021-06-06

Start date

2021-06-22

Completion date

Unknown

Last updated

2021-06-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

supratentorial brain lesions. Benign neoplasm of brain, supratentorial

Interventions

Intervention 1: Intervention group: infusion Ibuprofen.In group I, 400 mg of ibuprofen solution is infused intravenously over 30 minutes after removal of the brain lesion (at the beginning of Dora clo

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: All surgeries for supratentorial lesions No history of coagulation disorders No history of gastrointestinal disease No history of liver disease Discontinue drugs that cause coagulation disorders No history of heart disease No history of renal failure (creatinine clearance 165 U / L, aspartate transaminase>, 120 U / L Alkaline phosphatase> 345 U / L (three cases too normal) Inability to obtain the consent of the patient or companions No history of disorders due to hypersensitivity to ibuprofen, aspirin, nonsteroidal anti-inflammatory drugs, COX-2 inhibitors - Women in non-pregnancy status No long-term use of anticonvulsant drugs No dependence or tolerance on drugs Weight higher than 30 kg No gastrointestinal bleeding during the last 6 weeks Do not take warfarin, lithium or concomitant use of lasix and angiotensin converting enzyme inhibitors

Exclusion criteria

Exclusion criteria: Hematocrit less than 25% during surgery Reduction of body temperature to less than 36 ° C

Design outcomes

Primary

Measure	Time frame
Platelet function using PFa-100(CBC, PT, PTT, Ca2+, PFa-100, INR, Fibrinogen, serum osmolality, ABG). Timepoint: Once the Dora closure begins, a blood sample is taken first to measure coagulation abnormality using the PFa-100 test. Also, one hour after the injection is completed, blood samples are taken from both groups for the PFa-100 test. Method of measurement: The PFA-100 system is a platelet function analyzer designed to measure primary platelet-dependent homeostasis.(Platelet Function Assay or Platelet Function Analyzer): PFA-100.	—

Measure

Time frame

Platelet function using PFa-100(CBC, PT, PTT, Ca2+, PFa-100, INR, Fibrinogen, serum osmolality, ABG). Timepoint: Once the Dora closure begins, a blood sample is taken first to measure coagulation abnormality using the PFa-100 test. Also, one hour after the injection is completed, blood samples are taken from both groups for the PFa-100 test. Method of measurement: The PFA-100 system is a platelet function analyzer designed to measure primary platelet-dependent homeostasis.(Platelet Function Assay or Platelet Function Analyzer): PFA-100.

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Countries

Iran (Islamic Republic of)

Contacts

Public Contactsohrab salimi

Shahid Beheshti University of Medical Sciences

ssalimi@sbmu.ac.ir+98 21 7756 7840

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026