covid-19. COVID-19 Disease
Conditions
Interventions
Intervention 1: Intervention group1: 6 mg Melatonin (2 tablets of 3 mg melatonin made by Simorgh Pharmaceutical Company) is given orally every night for 5 nights. Intervention 2: Intervention group2:
Sponsors
Rasht University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: RT-PCR test positive for SARS-CoV-2 criteria for patients with moderate symptoms:evidence of lower respiratory disease( dyspnea, Chest compression ?..) oxygen saturation (SpO2) between 90 to 93% lung infiltrates30 breaths/min oxygen saturation (SpO2) 50%
Exclusion criteria
Exclusion criteria: patients with mild symptoms diabetes hypertension pregnant women those who have already been in clinical trial with other drugs. Age less than 18 years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| C-Reactive Protein serum levels. Timepoint: Morning of the first day (before the intervention), fourth day (day after the third intervention) and sixth day (day after the last intervention). Method of measurement: By ELISA.;Erythrocyte sedimentation rate serum levels. Timepoint: Morning of the first day (before the intervention), fourth day (day after the third intervention) and sixth day (day after the last intervention). Method of measurement: erythrocyte sedimentation rate per hour. | — |
Secondary
| Measure | Time frame |
|---|---|
| Outcome of the disease. Timepoint: Morning of the first day (before the intervention), fourth day (day after the third intervention) and sixth day (day after the last intervention). Method of measurement: Reduction of clinical sign and symptoms, no need for supplemental oxygen or mechanical ventilation.;Ferritin. Timepoint: Morning of the first day (before the intervention), fourth day (day after the third intervention) and sixth day (day after the last intervention). Method of measurement: by ELISA.;VitD(25OH). Timepoint: Morning of the first day (before the intervention), fourth day (day after the third intervention) and sixth day (day after the last intervention). Method of measurement: by ELISA.;Days of hospitalization. Timepoint: Until discharge or death. Method of measurement: Based on the days of hospitalization. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMalek Moien Ansar
Rasht University of Medical Sciences
Outcome results
None listed