The effect of ginger on the severity and frequency of chemotherapy-induced nausea and vomiting

Effect of ginger in control of nausea and vomiting in cancer patients receiving doxorubicin and platinum based chemotherapy

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210505051188N1

Enrollment

Registered

2021-06-25

Start date

2021-07-11

Completion date

Unknown

Last updated

2021-11-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chemotherapy induced nausea and vomiting. Adverse effect of antineoplastic and immunosuppressive drugs

Interventions

Intervention 1: Control group: The group receiving the placebo is that the treatment regimen consists of standard antiemetic and vomiting drugs, including 1 ampoule of granistron (Kytril) 3 mg, 1 ampo

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Age over 18 years Prescribing chemotherapy regimen based on doxorubicin and platinum compounds by the oncologist Ability to swallow capsules Having chemotherapy experience with nausea and vomiting Presence in the ward for 24 hours to evaluate anti-nausea drugs No history of nausea and vomiting for reasons other than chemotherapy Not receiving anti-nausea and vomiting drugs in the last 24 hours

Exclusion criteria

Exclusion criteria: Patients who do not sign the moral consent form. Patients who do not cooperate during treatment for any reason to continue treatment. History of any allergy to ginger Occurrence of nausea before chemotherapy for any reason Having any disease that causes nausea and vomiting, such as hepatitis, gastrointestinal obstruction Taking anticoagulants such as heparin The presence of blood disorders such as platelets less than 10,000 per microliter.

Design outcomes

Primary

Measure	Time frame
Frequency of acute and delayed nausea. Timepoint: Frequency of patient nausea up to 24 hours after chemotherapy for acute nausea and frequency of patients nausea p from 24 hours after chemotherapy to 4 days for delayed nausea. Method of measurement: Asking the patient.;Frequency of acute and delayed vomiting. Timepoint: Frequency of patient vomiting up to 24 hours after chemotherapy for acute vomiting and frequency of patients vomiting from 24 hours after chemotherapy to 4 days for delayed vomiting. Method of measurement: Asking the patient.;Severity of acute and delayed nausea. Timepoint: Severity of patient nausea up to 24 hours after chemotherapy for acute nausea and severity of patients nausea from 24 hours after chemotherapy to 4 days for delayed nausea. Method of measurement: Stepwise method that is taught to the patient.In this method, the base level is equal to the absence of nausea, steps 1 to 3 is equal to mild nausea, steps 4 to 6 is equal to moderate nausea, steps 7 to 9 is equal to severe nausea and step 10 is the most severe nausea possible.;Severity of acute and delayed vomiting. Timepoint: Severity of patient vomiting up to 24 hours after chemotherapy for acute vomiting and severity of patients vomiting from 24 hours after chemotherapy to 4 days for delayed vomiting. Method of measurement: Stepwise method that is taught to the patient.In this method, the base level is equal to the absence of nausea, steps 1 to 3 is equal to mild nausea, steps 4 to 6 is equal to moderate nausea, steps 7 to 9 is equal to severe nausea and step 10 is the most severe nausea possible.	—

Measure

Time frame

Frequency of acute and delayed nausea. Timepoint: Frequency of patient nausea up to 24 hours after chemotherapy for acute nausea and frequency of patients nausea p from 24 hours after chemotherapy to 4 days for delayed nausea. Method of measurement: Asking the patient.;Frequency of acute and delayed vomiting. Timepoint: Frequency of patient vomiting up to 24 hours after chemotherapy for acute vomiting and frequency of patients vomiting from 24 hours after chemotherapy to 4 days for delayed vomiting. Method of measurement: Asking the patient.;Severity of acute and delayed nausea. Timepoint: Severity of patient nausea up to 24 hours after chemotherapy for acute nausea and severity of patients nausea from 24 hours after chemotherapy to 4 days for delayed nausea. Method of measurement: Stepwise method that is taught to the patient.In this method, the base level is equal to the absence of nausea, steps 1 to 3 is equal to mild nausea, steps 4 to 6 is equal to moderate nausea, steps 7 to 9 is equal to severe nausea and step 10 is the most severe nausea possible.;Severity of acute and delayed vomiting. Timepoint: Severity of patient vomiting up to 24 hours after chemotherapy for acute vomiting and severity of patients vomiting from 24 hours after chemotherapy to 4 days for delayed vomiting. Method of measurement: Stepwise method that is taught to the patient.In this method, the base level is equal to the absence of nausea, steps 1 to 3 is equal to mild nausea, steps 4 to 6 is equal to moderate nausea, steps 7 to 9 is equal to severe nausea and step 10 is the most severe nausea possible.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohamadJavad Khodayar

Ahvaz University of Medical Sciences

khodayar-mj@ajums.ac.ir+98 61 3373 8379

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026