Comparison of the effects of aerobic exercises and conventional chest physiotherapy in cystic fibrosis

The effects of aerobic exercises compared to conventional chest physiotherapy on pulmonary function, functional capacity, sputum culture and quality of life in patients with cystic fibrosis: a randomized controlled trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210505051181N5

Enrollment

Registered

2023-02-19

Start date

2023-07-23

Completion date

Unknown

Last updated

2023-07-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cystic fibrosis with pulmonary symptoms. Cystic fibrosis with pulmonary manifestations

Interventions

Intervention 1: Group A (the main treatment of conventional chest physiotherapy and placebo of aerobic exercise): In this group, first the main treatment, i.e. conventional chest physiotherapy, and th

Eligibility

Sex/Gender

All

Age

6 Years to 18 Years

Inclusion criteria

Inclusion criteria: Confirmed diagnosis of cystic fibrosis based on positive sweat test or genetics test by a specialist doctor Age 6 to 18 years

Exclusion criteria

Exclusion criteria: Active hemoptysis, pneumothorax, hemodynamic instability, severe hypoxia, acute airway infection and cognitive disorders Having cardiac disease such as heart failure or arrhythmia, neurologic and orthopedic disorders, or chest trauma History of fever, IV antibiotics or hospitalization in the last 1 month Having severe uncontrolled gastroesophageal reflux Severe lung disease (FEV1% < 30%) Lung transplantation or in the awaiting list Requirement of additional oxygen with exercise Having uncontrolled diabetics Improper patient cooperation during treatment sessions Absence in 3 or more consecutive sessions

Design outcomes

Primary

Measure	Time frame
Forced expiratory volume in 1st second (FEV1). Timepoint: Before starting physiotherapy interventions and after completing 18 treatment sessions for each group. Method of measurement: spirometer.;6 minutes walk test (6MWT). Timepoint: Before starting physiotherapy interventions and after completing 18 treatment sessions for each group. Method of measurement: tape measure and field test.	—

Secondary

Measure	Time frame
Sputum culture. Timepoint: Before starting physiotherapy interventions and after completing 18 treatment sessions for each group. Method of measurement: Sterile container and laboratory culture kit.;Forced vital capacity (FVC). Timepoint: Before starting physiotherapy interventions and after completing 18 treatment sessions for each group. Method of measurement: spirometer.;Quality of life. Timepoint: Before starting physiotherapy interventions and after completing 18 treatment sessions for each group. Method of measurement: cystic fibrosis questionnaire - revised (CFQ-R).	—

Measure

Time frame

Sputum culture. Timepoint: Before starting physiotherapy interventions and after completing 18 treatment sessions for each group. Method of measurement: Sterile container and laboratory culture kit.;Forced vital capacity (FVC). Timepoint: Before starting physiotherapy interventions and after completing 18 treatment sessions for each group. Method of measurement: spirometer.;Quality of life. Timepoint: Before starting physiotherapy interventions and after completing 18 treatment sessions for each group. Method of measurement: cystic fibrosis questionnaire - revised (CFQ-R).

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactNadia Hamedi

Iran University of Medical Sciences

nnn00887@gmail.com+98 26 3445 1027

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 10, 2026