Evaluation of the effect of a mouthwash containing sumac extract on patients with denture stomatitis

Comparison of the therapeutic effect of mouthwash containing sumac extract and nystatin suspension in patients with denture stomatitis

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210429051121N1

Enrollment

Registered

2021-11-29

Start date

2021-09-27

Completion date

Unknown

Last updated

2022-01-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Denture stomatitis - severe palate infection.

Interventions

Intervention 1: Intervention group: Sumac mouthwash will be gargled 3 times a day (20 drops each time). Intervention 2: Control group: Nystatin 100000u / ml mouthwash will be gargled 3 times a day (20

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients referred to the clinic of Sari Dental School due to maxillary complete denture Patients with denture stomatitis (type II and III) with confirmation of denture stomatitis in patients by an oral pathologist

Exclusion criteria

Exclusion criteria: Patients with a history of using antifungal drugs, antibiotics and corticosteroids in a last month, Allergy to nystatin mouthwash, Patients with immunodeficiency, Alzheimer's, psychological disorders, chewing muscle disorder, Patients with inability to use mouthwash and patients with loose and discolored dentures,

Design outcomes

Primary

Measure	Time frame
Size of denture stomatitis lesions before and after using Sumac mouthwash and nystatin mouthwash. Timepoint: Patients are asked to hold the mouthwash in their mouth for 1 minute and to avoid eating and drinking for at least 1 hour after using the mouthwash. Treatment will continue for 2 weeks and erythematous lesions will be checked weekly. Method of measurement: The length and width of erythematous lesions in the area under the denture are assessed by a calliper and by a specialist on a centimeter basis. Photographic waste will also be prepared each week. At the beginning and end of the study, smear and culture (Sabouraud's dextrose agar) will be prepared from the infected area of ??the palate. Patients and examiners will not be aware of the type of drug used and the type of study group. In physiological serum in a numbered test tube, the lesion surface was sampled. Then, saliva and plaque samples were immediately transferred to the specialized laboratory of Mazandaran Science and Technology Park for mushroom cultivation and immediately cultured in Saburodextrose agar solid medium next to the flame and under the hood.	—

Measure

Time frame

Size of denture stomatitis lesions before and after using Sumac mouthwash and nystatin mouthwash. Timepoint: Patients are asked to hold the mouthwash in their mouth for 1 minute and to avoid eating and drinking for at least 1 hour after using the mouthwash. Treatment will continue for 2 weeks and erythematous lesions will be checked weekly. Method of measurement: The length and width of erythematous lesions in the area under the denture are assessed by a calliper and by a specialist on a centimeter basis. Photographic waste will also be prepared each week. At the beginning and end of the study, smear and culture (Sabouraud's dextrose agar) will be prepared from the infected area of ??the palate. Patients and examiners will not be aware of the type of drug used and the type of study group. In physiological serum in a numbered test tube, the lesion surface was sampled. Then, saliva and plaque samples were immediately transferred to the specialized laboratory of Mazandaran Science and Technology Park for mushroom cultivation and immediately cultured in Saburodextrose agar solid medium next to the flame and under the hood.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaede Salehi

Mazandaran University of Medical Sciences

am.shafaroudi@gmail.com+98 11 3324 4894

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026