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Comparison of The Routine Respiratory and Gradual Device-guided Slow Breathing Exercises on Inflammation and Heart Rate Variability in Patients With Heart Failure

Comparison of The Routine Respiratory and Gradual Device-guided Slow Breathing Exercises on Inflammation and Heart Rate Variability in Patients With Heart Failure

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20210426051093N1
Enrollment
36
Registered
2021-12-04
Start date
2021-12-11
Completion date
Unknown
Last updated
2023-11-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic heart Failure. Heart failure

Interventions

Intervention 1: Control group: Individuals only receive standard medication treatment. Intervention 2: Intervention group
in the second group, or Routine Breathing Exercises group, for four weeks, in the first week for 20 minutes, and with an increase of 3.5 minutes at the beginning of the second, third, and fourth weeks

Sponsors

Tarbiat Modares University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
50 Years to 70 Years

Inclusion criteria

Inclusion criteria: Class II and III heart failure based on NYHA criteria Having suffered from heart failure for the past 3–5 years Clinical status and stable hemodynamics at least one month before entering the study Ejection fraction less than 50% based on echocardiography Being treated with standard medication Age range: 50 to 70 years

Exclusion criteria

Exclusion criteria: Unstable angina and complex ventricular arrhythmias The occurrence of myocardial infarction in the past year having pacemaker During the last six months, have bypass surgery or angioplasty. Participate in other exercise programs six months before the start of the study. The existence of musculoskeletal disorders that prevent normal walking Existence of cognitive disorders Lack of personal desire to cooperate History of lung disease, smoking, angina, heart attack or heart surgery (less than six months), orthopedic or neurological diseases, steroid therapy, or chemotherapy

Design outcomes

Primary

MeasureTime frame
The basic rate of respiration. Timepoint: 48 hours before the intervention and 48 hours after the end of four weeks of intervention. Method of measurement: Average rate of five minutes of respiration based on respirometer biofeedback.;Inflammation. Timepoint: 48 hours before the intervention and 48 hours after the end of four weeks of intervention. Method of measurement: According to the report of TNF-alpha in an enzyme-linked immunosorbent assay device.;Heart Rate Variability. Timepoint: 48 hours before the intervention and 48 hours after the end of four weeks of intervention. Method of measurement: Holter monitoring device.

Secondary

MeasureTime frame
Quality of Life. Timepoint: 48 hours before the intervention and 48 hours after the end of four weeks of intervention. Method of measurement: Minnesota Quality of Life Questionnaire Score.;Cholesterol. Timepoint: 48 hours before the intervention and 48 hours after the end of four weeks of intervention. Method of measurement: Based on an autoanalyzer device's report from a person's blood serum.;Triglyceride. Timepoint: 48 hours before the intervention and 48 hours after the end of four weeks of intervention. Method of measurement: From a person's blood serum based on the report of an autoanalyzer device.;High-Density Lipoprotein (HDL). Timepoint: 48 hours before the intervention and 48 hours after the end of four weeks of intervention. Method of measurement: From a person's blood serum based on the report of an autoanalyzer device.;Low-Density Lipoprotein (LDL). Timepoint: 48 hours before the intervention and 48 hours after the end of four weeks of intervention. Method of measurement: From a person's blood serum based on the report of an autoanalyzer device.;Systolic blood pressure at rest. Timepoint: 48 hours before the intervention and 48 hours after the end of four weeks of intervention. Method of measurement: According to the average Holter blood pressure report.;Diastolic blood pressure at rest. Timepoint: 48 hours before the intervention and 48 hours after the end of four weeks of intervention. Method of measurement: According to the average Holter blood pressure report.;Rate of perceived exertion. Timepoint: 48 hours before and after the six-minute walk test and 48 hours after the end of four weeks of intervention before and after the six-minute walk test. Method of measurement: Based on the Borg scale.;Standard Deviation of NN Intervals (SDNN). Timepoint: 48 hours before the intervention and 48 hours after the end of four weeks of intervention. Method of measurement: According to the report of the cardiac Holter device.;Root Mean Square of Successive Differen

Countries

Iran (Islamic Republic of)

Contacts

Public ContactRoya ravanbod

Tarbiat Modares University

ravanbod@modares.ac.ir+98 21 8288 4510

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026