The effect of omega-3 supplementation on endothelial function, vascular structure and metabolic parameters in adolescents with type 1 diabetes

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210419051010N1

Enrollment

Registered

2021-04-29

Start date

2021-05-20

Completion date

Unknown

Last updated

2021-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 1 diabetes. Type 1 diabetes mellitus

Interventions

Intervention 1: Intervention group: Omega3. Intervention 2: Control group: Placebo.

Eligibility

Sex/Gender

All

Age

10 Years to 18 Years

Inclusion criteria

Inclusion criteria: Adolescents 10 to 18 years Body mass index of people between 5 and 85 percent Having type 1 diabetes as determined by doctor and receiving insulin routine At least 5 years have passed since the diagnosis of type 1 diabetes Willingness to cooperate

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Flow mediated dilation. Timepoint: At the beginning of the study and 12 weeks after starting the omega-3 supplementation. Method of measurement: Doppler ultrasound device.	—

Secondary

Measure	Time frame
Carotid intima-media thickness. Timepoint: At the beginning of the study and 12 weeks after starting the omega-3 supplement. Method of measurement: Doppler ultrasound device.;Fasting plasma glucose. Timepoint: Before and after intervention. Method of measurement: Enzyme essay.;Total cholesterol. Timepoint: Before and after intervention. Method of measurement: Photometric.;High density lipoprotein. Timepoint: Before and after intervention. Method of measurement: Photometric.;Low density lipoprotein. Timepoint: Before and after intervention. Method of measurement: Calculation.;Triglyceride. Timepoint: Before and after intervention. Method of measurement: Photometric.;Insulin. Timepoint: Before and after intervention. Method of measurement: ELISA.;Hemoglobin A1C. Timepoint: Before and after intervention. Method of measurement: Enzymatic method.;BMI for age Z-score. Timepoint: Before and after intervention. Method of measurement: Calculation.;Weight. Timepoint: Before and after intervention. Method of measurement: Scale.;Physical activity. Timepoint: Before and after intervention. Method of measurement: Questionnaire.;Hs-CRP. Timepoint: Before and after intervention. Method of measurement: ELISA.;ESR. Timepoint: Before and after intervention. Method of measurement: Measurement of erythrocyte sedimentation rate with a special tube.;Diastolic blood pressure. Timepoint: Before and after intervention. Method of measurement: Manometer.;Systolic blood pressure. Timepoint: Before and after intervention. Method of measurement: Manometer.;Creatinine. Timepoint: Before and after intervention. Method of measurement: Enzymatic method.;Blood urea nitrogen concentration. Timepoint: Before and after intervention. Method of measurement: Diacetylmonoxim.;Proteinuria. Timepoint: Before and after intervention. Method of measurement: 24-hour urine measurement.;Daily insulin received. Timepoint: Before and after intervention. Method of measurement: questionnaire.;HOMA-IR. Timepoint: Before	—

Measure

Time frame

Carotid intima-media thickness. Timepoint: At the beginning of the study and 12 weeks after starting the omega-3 supplement. Method of measurement: Doppler ultrasound device.;Fasting plasma glucose. Timepoint: Before and after intervention. Method of measurement: Enzyme essay.;Total cholesterol. Timepoint: Before and after intervention. Method of measurement: Photometric.;High density lipoprotein. Timepoint: Before and after intervention. Method of measurement: Photometric.;Low density lipoprotein. Timepoint: Before and after intervention. Method of measurement: Calculation.;Triglyceride. Timepoint: Before and after intervention. Method of measurement: Photometric.;Insulin. Timepoint: Before and after intervention. Method of measurement: ELISA.;Hemoglobin A1C. Timepoint: Before and after intervention. Method of measurement: Enzymatic method.;BMI for age Z-score. Timepoint: Before and after intervention. Method of measurement: Calculation.;Weight. Timepoint: Before and after intervention. Method of measurement: Scale.;Physical activity. Timepoint: Before and after intervention. Method of measurement: Questionnaire.;Hs-CRP. Timepoint: Before and after intervention. Method of measurement: ELISA.;ESR. Timepoint: Before and after intervention. Method of measurement: Measurement of erythrocyte sedimentation rate with a special tube.;Diastolic blood pressure. Timepoint: Before and after intervention. Method of measurement: Manometer.;Systolic blood pressure. Timepoint: Before and after intervention. Method of measurement: Manometer.;Creatinine. Timepoint: Before and after intervention. Method of measurement: Enzymatic method.;Blood urea nitrogen concentration. Timepoint: Before and after intervention. Method of measurement: Diacetylmonoxim.;Proteinuria. Timepoint: Before and after intervention. Method of measurement: 24-hour urine measurement.;Daily insulin received. Timepoint: Before and after intervention. Method of measurement: questionnaire.;HOMA-IR. Timepoint: Before

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNahid Aryaeian

Iran University of Medical Sciences

nah_arya2002@yahoo.com+98 21 86709

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 13, 2026