Evaluation of the therapeutic effect of buspirone in improving the dysphagia of patients with ineffective esophageal motility.

Evaluation of the therapeutic effect of buspirone in improving the dysphagia of patients with ineffective esophageal motility

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210418051005N1

Enrollment

Registered

2021-05-29

Start date

2021-06-05

Completion date

Unknown

Last updated

2021-06-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Ineffective esophageal motility. Condition 2: Dysphagia. Motility disorders of oesophagus Dysphagia

Interventions

Intervention 1: Intervention group: Group 1: Patients are prescribed 40 mg of pantoprazole daily for 30 days. Intervention 2: Intervention group: Group 2: Patients are prescribed 40 mg of pantoprazole

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Ineffective esophageal motility Age between 18 and 70 Consent Patient with symptom

Exclusion criteria

Exclusion criteria: Cancer Mechanical obstruction Eosinophilic esophagitis Diabetes Opium addiction Collagen vascular disease Muscle disorders

Design outcomes

Primary

Measure	Time frame
Mayo Score. Timepoint: Before intervention and then after 30 days. Method of measurement: Mayo Score.;Esophageal sphincter (LES) resting pressure. Timepoint: Before intervention and then after 30 days. Method of measurement: Manometer.;Distal contractile integral pressure. Timepoint: Before intervention and then after 30 days. Method of measurement: Manometer.;Integrated Relaxation Pressure (IRP). Timepoint: Before intervention and then after 30 days. Method of measurement: Manometer.	—

Measure

Time frame

Mayo Score. Timepoint: Before intervention and then after 30 days. Method of measurement: Mayo Score.;Esophageal sphincter (LES) resting pressure. Timepoint: Before intervention and then after 30 days. Method of measurement: Manometer.;Distal contractile integral pressure. Timepoint: Before intervention and then after 30 days. Method of measurement: Manometer.;Integrated Relaxation Pressure (IRP). Timepoint: Before intervention and then after 30 days. Method of measurement: Manometer.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactForoogh Alborzi Avanaki

Tehran University of Medical Sciences

falborzi@sina.ac.ir+98 21 6119 0000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026