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The effect of melatonin in addiction to opium patients, candidates for elective lumbar spine surgery

The effect of melatonin on drug consumption and hemodynamic responses after laryngoscopy in addiction to opium patients, candidates for elective lumbar spine surgery

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20210415050983N9
Enrollment
64
Registered
2024-11-18
Start date
2024-11-25
Completion date
Unknown
Last updated
2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lumbar Discopathy. Intervertebral disc disorders with myelopathy, thoracolumbar region

Interventions

Intervention 1: Intervention group: The group receiving melatonin: two tablets (3 mg each from Razak pharmaceutical company) of melatonin will be given 120 minutes before induction of anesthesia. Int

Sponsors

Shahid Beheshti University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Patient consent to participate in the study ASA I , II Having opium addiction

Exclusion criteria

Exclusion criteria: Difficult airway BMI More than 30 kg/m2 Patients who were taking anti-anxiety, sedative, anti-psychotic or anti-epileptic drugs Patients with sleep disorder, gastroesophageal reflux and hiatus hernia Known allergy to melatonin A known case of coronary artery disease

Design outcomes

Primary

MeasureTime frame
Blood pressure. Timepoint: Before induction of anesthesia, after laryngoscopy up to 15 minutes. Method of measurement: Pressure cuff and arterial line.;Heart rate. Timepoint: Before induction of anesthesia, after laryngoscopy up to 15 minutes. Method of measurement: ECG.

Secondary

MeasureTime frame
The amount of narcotic use. Timepoint: End of surgery. Method of measurement: How many micrograms of narcotics have been given?.;The amount of hypnotic for induction maintenance of anesthesia. Timepoint: End of surgery. Method of measurement: The amount of cc used.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSogol Asgari

Shahid Beheshti University of Medical Sciences

Drasgari98429@gmail.com+98 21 5541 9005

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026