The effect of adding low dose of epinephrine with intrathecal bupivacaine and fentanyl on hemodynamic stability of patients undergoing orthopedic lower limb surgery:A Clinical trial study

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210415050976N4

Enrollment

128

Registered

2021-06-13

Start date

2021-10-02

Completion date

Unknown

Last updated

2021-06-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hemodynamics in lower limb orthopedic patients. Other acute postprocedural pain

Interventions

Intervention 1: Intervention group: They receive 0.2 mg epinephrine + 25 micrograms fentanyl + 10 mg bupivacaine intrathecally and in a single dose. Intervention 2: Control group: 10 mg bupivacaine +

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Anesthesia class one and two

Exclusion criteria

Exclusion criteria: Diabetes History of cardiovascular disease Shortness of breath Kidney or liver disease

Design outcomes

Primary

Measure	Time frame
Blood pressure. Timepoint: Before prescribing the studied drug, before spinal anesthesia, after anesthesia and then every half hour until the end of surgery and during recovery will be measured and recorded. Method of measurement: Monitoring.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNavid Kalani

Jahrom University of Medical Sciences

k.navid@jums.ac.ir+98 71 2536 5231

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026