central obesity. Overweight and obesity
Conditions
Interventions
Intervention 1: The treatment group (n= 25) including subjects with central obesity based on NCEP-ATP III. Curcumin (C3 complex) at a dose of 500 mg/day plus 5 mg piperine is taken orally over 8 weeks
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Signed informed consent form Aged 18-65 years old Subjects with central obesity based on NCEP-ATP III guidelines
Exclusion criteria
Exclusion criteria: History of systemic diseases History of cardiac ischemia Pregnancy Breastfeeding Hepatic failure Biliary obstruction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Maximal oxygen consumption (V?O2max). Timepoint: Before the intervention and 8 weeks after taking supplement or placebo. Method of measurement: cardiopulmonary exercise testing. | — |
Secondary
| Measure | Time frame |
|---|---|
| Ratio of minute ventilation to carbon dioxide output (VE/V CO2). Timepoint: Before the intervention and 8 weeks after taking supplement or placebo. Method of measurement: cardiopulmonary exercise testing (CPET).;Dead-space ventilation (Vd/Vt). Timepoint: Before the intervention and 8 weeks after taking supplement or placebo. Method of measurement: cardiopulmonary exercise testing (CPET).;Alveolar-arterial oxygen pressure gradient [P(A-a)O2]. Timepoint: Before the intervention and 8 weeks after taking supplement or placebo. Method of measurement: cardiopulmonary exercise testing (CPET).;Blood pressure. Timepoint: Before the intervention and 8 weeks after taking supplement or placebo. Method of measurement: sphygmomanometer.;Fasting blood sugar. Timepoint: Before the intervention and 8 weeks after taking supplement or placebo. Method of measurement: Auto analyzer.;Lipid profile (Total cholestrol, Triglyceride, High density lipoprotein, Low density lipoprotein). Timepoint: Before the intervention and 8 weeks after taking supplement or placebo. Method of measurement: Auto analyzer.;Anaerobic threshold. Timepoint: Before the intervention and 8 weeks after taking supplement or placebo. Method of measurement: cardiopulmonary exercise testing (CPET).;Peak heart rate. Timepoint: Before the intervention and 8 weeks after taking supplement or placebo. Method of measurement: cardiopulmonary exercise testing (CPET).;Heart rate reserve. Timepoint: Before the intervention and 8 weeks after taking supplement or placebo. Method of measurement: cardiopulmonary exercise testing (CPET).;Peak work. Timepoint: Before the intervention and 8 weeks after taking supplement or placebo. Method of measurement: cardiopulmonary exercise testing (CPET).;Ventilator reserve. Timepoint: Before the intervention and 8 weeks after taking supplement or placebo. Method of measurement: cardiopulmonary exercise testing (CPET).;Respiratory frequency. Timepoint: cardiopulmonary exercise testing (CPET). Method | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMaryam Saberi-Karimian
Mashhad University of Medical Sciences
Outcome results
None listed