Effect of curcumin on the prevention of contrast induced nephropathy

The effects of curcumin on the prevention of contrast induced nephropathy: A randomized double blind clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210413050958N2

Enrollment

227

Registered

2021-12-18

Start date

2022-04-21

Completion date

Unknown

Last updated

2022-01-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nephropathy induced by contrast agents. Nephropathy induced by other drugs, medicaments and biological substances

Interventions

Intervention 1: Intervention group: In treatment group (n=227), curcumin is taken orally in subjects will be received from two days before I.V. contrast agent injection up to 48 hours after the interv

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: All subjects who receive IV. contrast agent (except renal artery angiography candidates)

Exclusion criteria

Exclusion criteria: Hepatic failure (Child-Pugh Score B or C) Biliary obstruction End-stage renal insufficiency (eGFR less than 15 mL/min) Acute renal insufficiency (BUN/Creatinine more than 20) A history of reaction to contrast media Taking potentially nephrotoxic medicines (48 h before and 24 h after the procedure) Pulmonary oedema Gastrointestinal disorders (such as diarrhea, vomiting, dehydration, bleeding, malabsorption, indigestion, etc.) Multiple myeloma Exposure to contrast media within 7 days before the procedure Pregnancy Taking N-acetyl cysteine, teofiline, dopamine, fenoldopam, manitol, and NaHCO3 within 48 h before coronary angiography.

Design outcomes

Primary

Measure	Time frame
Increased serum creatinine level. Timepoint: Before the intervention and 48 hours after contrast agent injection. Method of measurement: Creatinine kit.	—

Secondary

Measure	Time frame
Blood urea nitrogen. Timepoint: Before the intervention and 48 hours after contrast agent injection. Method of measurement: Blood urea nitrogen kit.;Cell blood count. Timepoint: Before the intervention and 48 hours after contrast agent injection. Method of measurement: Sysmex Cell Counter.;Creatinin. Timepoint: Before the intervention and 48 hours after contrast agent injection. Method of measurement: Serum creatinin kit.	—

Measure

Time frame

Blood urea nitrogen. Timepoint: Before the intervention and 48 hours after contrast agent injection. Method of measurement: Blood urea nitrogen kit.;Cell blood count. Timepoint: Before the intervention and 48 hours after contrast agent injection. Method of measurement: Sysmex Cell Counter.;Creatinin. Timepoint: Before the intervention and 48 hours after contrast agent injection. Method of measurement: Serum creatinin kit.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Saberi-Karimian

Mashhad University of Medical Sciences

maryamsabery2012@gmail.com+98 51 3764 3808

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026