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?Effects of Metronidazole gel and tablets in gingival disease treatment

Effects of local and systemic Metronidazole as adjunctive treatment in patients suffering from chronic periodontitis

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20210408050898N1
Enrollment
30
Registered
2021-04-27
Start date
2021-05-01
Completion date
Unknown
Last updated
2021-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Periodontitis. Chronic periodontitis

Interventions

Intervention 1: Control group: Receiving of Scaling and Root Planing by ultrasonic cavitron. Intervention 2: First intervention group: In this group, after Scaling and Root Planing by ultrasonic cavit

Sponsors

Oroumia University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
30 Years to No maximum

Inclusion criteria

Inclusion criteria: Patient diagnosed with chronic periodontitis with at least three non-adjacent pockets with probing depth equal to or greater than 4 mm. Patients with systemic health. Patients who have not taken any anti-inflammatory drugs or antibiotics in the last six months. Patients with at least 15 teeth (except third molars) in their mouth. Patients with proper cooperation. Patients who have signed an informed written consent form.

Exclusion criteria

Exclusion criteria: Patients with medical problems who need antibiotic prophylaxis or treatment intervention. Patients who have had periodontal treatment in the last six months. Patients who have used drugs that affect their periodontal status (such as antibiotics, anti-inflammatory drugs, anticonvulsants, immunosuppressive drugs, and calcium channel blockers) in the last six months. Patients who have undergone orthodontic treatment. Pregnant and lactating patients. Patients with systemic diseases such as diabetes and immunological disorders. O’Leary plaque index more than 15% after proper oral hygiene training. History of Metronidazole allergy.

Design outcomes

Primary

MeasureTime frame
Pocket Probing Depth. Timepoint: At the beginning of the study (before the intervention) and three months after the intervention. Method of measurement: Periodontal Probe.;Clinical Attachment Level. Timepoint: At the beginning of the study (before the intervention) and three months after the intervention. Method of measurement: Periodontal Probe.;Bleeding On Probing. Timepoint: At the beginning of the study (before the intervention) and three months after the intervention. Method of measurement: Visual.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactEhsan Hooshyar

Oroumia University of Medical Sciences

houshyar.e@umsu.ac.ir+98 44 3336 3590

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 5, 2026